Sesame Lignans Suppress Age-Related Cognitive Decline in Senescence-Accelerated Mice

• Published in: Nutrients 2019-07, Vol.11 (7), p.1582
• Main Authors: Shimoyoshi, Satomi, Takemoto, Daisuke, Ono, Yoshiko, Kitagawa, Yoshinori, Shibata, Hiroshi, Tomono, Susumu, Unno, Keiko, Wakabayashi, Keiji
• Format: Article
• Language: English
• Subjects: Age; Aging; Alzheimer's disease; Animal cognition; Animals; Body weight; Body Weight - drug effects; Brain; Brain - drug effects; Cerebral cortex; Cognitive ability; cognitive decline; Cognitive Dysfunction - drug therapy; Colorectal cancer; Dementia; Dementia disorders; depression; episesamin; Free radicals; Geriatrics; Humans; Humidity; Lignans; Lignans - administration & dosage; Lignans - pharmacology; Lipid peroxidation; Lipids; Liver; Male; Mice; Mice, Inbred Strains; Neurotoxicity; Nursing; Older people; Organ Size; Oxidative stress; Physiology; Psychiatry; Public health; Quality of life; reactive carbonyl; SAMP10; Senescence; senescence-accelerated mouse; sesame lignans; sesamin; Sesamum - chemistry; Survival Analysis; Systematic review; Vitamin E
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu11071582

Sesame lignans, which are biologically active compounds present in sesame seeds and oil, are known to have neuroprotective effects in several models of brain dysfunction. However, the effects of sesame lignans on age-related brain dysfunction are not clear and were thus investigated in the present study using a senescence-accelerated mouse (SAMP10). Two-month-old male SAMP10 mice were administrated a basal diet with 0% or 0.05% sesame lignans for two months, or with 0%, 0.02%, or 0.05% sesame lignans for 10 months and subjected to step-through passive avoidance tasks and forced swim tests. Reactive carbonyl species (RCs) were evaluated as markers of oxidative stress using a recently developed comprehensive analytical method. Both learning time in passive avoidance tasks and immobile time in forced swim tests became longer with aging ( < 0.05). However, the administration of sesame lignans significantly ameliorated age-related effects in both tests ( < 0.05). Age-related increases in RCs such as 4-hydroxy-2-nonenal in the cerebral cortex and liver were reduced in mice fed sesame lignans. These results suggest that sesame lignans can prevent age-related brain dysfunction via anti-oxidative activity.