16S rRNA Sequencing Analysis of the Gut Microbiota in Broiler Chickens Prophylactically Administered with Antimicrobial Agents

In poultry production, gut microbiota (GM) plays a pivotal role and influences different host functions related to the efficiency of production performances. Antimicrobial (AM) use is one of the main factors affecting GM composition and functions. Although several studies have focused their attentio...

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Bibliographic Details
Published in:Antibiotics (Basel) 2021-02, Vol.10 (2), p.146
Main Authors: Cuccato, Matteo, Rubiola, Selene, Giannuzzi, Diana, Grego, Elena, Pregel, Paola, Divari, Sara, Cannizzo, Francesca Tiziana
Format: Article
Language:English
Subjects:
16S rRNA sequencing
Antiinfectives and antibacterials
Antimicrobial agents
Bacteria
broiler
caecum
coccidiostat
Composition
Cyanobacteria
Drug resistance
Gene sequencing
Ileum
Infectious diseases
Intestinal microflora
Metabolism
Microbiota
Phylogenetics
Physiology
Poultry
Poultry production
prophylaxis
rRNA 16S
Sequence analysis
Small intestine
Variance analysis
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Summary:In poultry production, gut microbiota (GM) plays a pivotal role and influences different host functions related to the efficiency of production performances. Antimicrobial (AM) use is one of the main factors affecting GM composition and functions. Although several studies have focused their attention on the role of AMs as growth promoters in the modulation of GM in broilers, the consequences of higher AM concentrations administered during prophylactic treatments need to be better elucidated. For this purpose, 16S rRNA gene sequencing was performed to evaluate the impact of different prophylactic AM protocols on the composition and diversity of the broiler GM. Diversity analysis has shown that AM treatment significantly affects alpha diversity in ileum and beta diversity in both ileum and caecum. In ileal samples, the family has been shown to be particularly affected by AM treatments. AMs have been demonstrated to affect GM composition in broiler. These findings indicate that withdrawal periods were not enough for the restoral of the original GM. Further studies are needed for a better elucidation of the negative effects caused by an altered GM in broilers.
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics10020146