Methotrexate and Cyclosporine Treatments Modify the Activities of Dipeptidyl Peptidase IV and Prolyl Oligopeptidase in Murine Macrophages

Analysis of the effects of cyclosporine A (25–28 mgkg−1) and/or methotrexate (0.1 mgkg−1) treatments on dipeptidyl peptidase IV (DPPIV) and prolyl oligopeptidase (POP) activities and on algesic response in two distinct status of murine macrophages (Mφs) was undertaken. In resident Mφs, DPPIV and POP...

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Published in:Clinical & developmental immunology 2008-01, Vol.2008 (2008), p.1-9
Main Authors: Mendes, Mariana Trivilin, Nascimento, N. G., Teixeira, C. F. P., Silveira, Paulo Flavio
Format: Article
Language:English
Subjects:
Animals
Cyclosporine - administration & dosage
Cyclosporine - pharmacology
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - metabolism
Drug Therapy, Combination
Enzyme Inhibitors - administration & dosage
Enzyme Inhibitors - pharmacology
Enzymes
Immunology
Immunosuppressive Agents - administration & dosage
Immunosuppressive Agents - pharmacology
Inflammation - drug therapy
Macrophages, Peritoneal - drug effects
Macrophages, Peritoneal - enzymology
Macrophages, Peritoneal - immunology
Male
Medical research
Methotrexate
Methotrexate - administration & dosage
Methotrexate - pharmacology
Mice
Nitric oxide
Pain - drug therapy
Proteins
Rodents
Serine Endopeptidases - metabolism
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description Analysis of the effects of cyclosporine A (25–28 mgkg−1) and/or methotrexate (0.1 mgkg−1) treatments on dipeptidyl peptidase IV (DPPIV) and prolyl oligopeptidase (POP) activities and on algesic response in two distinct status of murine macrophages (Mφs) was undertaken. In resident Mφs, DPPIV and POP were affected by neither individual nor combined treatments. In thioglycolate-elicited Mφs, methotrexate increased DPPIV (99–110%) and POP (60%), while cyclosporine inhibited POP (21%). Combined treatment with both drugs promoted a rise (51–84%) of both enzyme activities. Only cyclosporine decreased (42%) the tolerance to algesic stimulus. Methotrexate was revealed to exert prevalent action over that of cyclosporine on proinflammatory Mφ POP. The opposite effects of methotrexate and cyclosporine on POP activity might influence the availability of the nociceptive mediators bradykinin and substance P in proinflammatory Mφs. The exacerbated response to thermally induced algesia observed in cyclosporine-treated animals could be related to upregulation of those mediators.
doi_str_mv 10.1155/2008/794050
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Methotrexate was revealed to exert prevalent action over that of cyclosporine on proinflammatory Mφ POP. The opposite effects of methotrexate and cyclosporine on POP activity might influence the availability of the nociceptive mediators bradykinin and substance P in proinflammatory Mφs. 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subjects Animals
Cyclosporine - administration & dosage
Cyclosporine - pharmacology
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - metabolism
Drug Therapy, Combination
Enzyme Inhibitors - administration & dosage
Enzyme Inhibitors - pharmacology
Enzymes
Immunology
Immunosuppressive Agents - administration & dosage
Immunosuppressive Agents - pharmacology
Inflammation - drug therapy
Macrophages, Peritoneal - drug effects
Macrophages, Peritoneal - enzymology
Macrophages, Peritoneal - immunology
Male
Medical research
Methotrexate
Methotrexate - administration & dosage
Methotrexate - pharmacology
Mice
Nitric oxide
Pain - drug therapy
Proteins
Rodents
Serine Endopeptidases - metabolism
title Methotrexate and Cyclosporine Treatments Modify the Activities of Dipeptidyl Peptidase IV and Prolyl Oligopeptidase in Murine Macrophages
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