The time scales of irreversibility in spontaneous brain activity are altered in obsessive compulsive disorder

We study how obsessive-compulsive disorder (OCD) affects the complexity and time-reversal symmetry-breaking (irreversibility) of the brain resting-state activity as measured by magnetoencephalography (MEG). Comparing MEG recordings from OCD patients and age/sex matched control subjects, we find that...

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Bibliographic Details
Published in:Frontiers in psychiatry 2023-05, Vol.14, p.1158404-1158404
Main Authors: Bernardi, Davide, Shannahoff-Khalsa, David, Sale, Jeff, Wright, Jon A, Fadiga, Luciano, Papo, David
Format: Article
Language:English
Subjects:
dynamical disease
obsessive-compulsive disorder
permutation entropy
Psychiatry
spontaneous brain activity
time scales
time-reversal symmetry
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Summary:We study how obsessive-compulsive disorder (OCD) affects the complexity and time-reversal symmetry-breaking (irreversibility) of the brain resting-state activity as measured by magnetoencephalography (MEG). Comparing MEG recordings from OCD patients and age/sex matched control subjects, we find that irreversibility is more concentrated at faster time scales and more uniformly distributed across different channels of the same hemisphere in OCD patients than in control subjects. Furthermore, the interhemispheric asymmetry between homologous areas of OCD patients and controls is also markedly different. Some of these differences were reduced by 1-year of Kundalini Yoga meditation treatment. Taken together, these results suggest that OCD alters the dynamic attractor of the brain's resting state and hint at a possible novel neurophysiological characterization of this psychiatric disorder and how this therapy can possibly modulate brain function.
ISSN:1664-0640
1664-0640
DOI:10.3389/fpsyt.2023.1158404