Novel phytosterol with Antimicrobial Potential of Digera muricata Mart. from Chittorgarh Region, India

Digera muricata Mart, a plant having therapeutic characteristics that has been utilised traditionally, belongs to the Amaranthaceae family, and a promising source of specific natural products utilized as antioxidant, prophylactic, antimicrobial, anthelmintic, anti-diabetic, and allelopathic agent. I...

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Bibliographic Details
Published in:Journal of pure & applied microbiology : an international research journal of microbiology 2024-09, Vol.18 (3), p.1648-1660
Main Authors: Tomer, Nalini, Sharma, Anil Kumar, Ali, Mohammad Irfan, Mathur, Manas, Nagar, Hariom, Dhakar, Ramgopal, Sen, Amit, Zaidi, Zoya, Moin, Sarmad
Format: Article
Language:English
Subjects:
antifungal
antimicrobial
digera muricata
Escherichia coli
Health aspects
molecular docking
phytosterol
Phytosterols
Tetracycline
Tetracyclines
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Summary:Digera muricata Mart, a plant having therapeutic characteristics that has been utilised traditionally, belongs to the Amaranthaceae family, and a promising source of specific natural products utilized as antioxidant, prophylactic, antimicrobial, anthelmintic, anti-diabetic, and allelopathic agent. In the present study, a biologically active phytosterol was isolated from Digera muricata Mart. The isolated compound was characterized by 13C, 1H NMR, FTIR, and HRMS. Characterization of the isolate was done by antimicrobial assay, and molecular docking. The antimicrobial potential of the isolated phytosterol (50 µl) against Streptococcus pyogenes was found to be maximum (ZOI-20.0 ± 1.0), followed by Streptococcus agalactiae (ZOI-11.3±1.5), Candida albicans (ZOI- 09.0 ± 1.0), Klebsiella pneumonia (ZOI-8.6 ± 1.5) and Escherichia coli (ZOI-8.6 ± 1.5). The molecular docking results indicate that the phytosterol binds to the receptor 1AI9 at the 32th and 58th positions; 1KZN receptor at the 76th position, the 5L3J receptor at the 46th (ASN) and 136th (ARG) position; 7WIJ receptor at the 419th (ARG) and 582th (ASP) and 585th (ASN) positions.
ISSN:0973-7510
2581-690X
DOI:10.22207/JPAM.18.3.14