Taxifolin Modulates Transcriptomic Response to Heat Stress in Rainbow Trout, Oncorhynchus mykiss

Taxifolin is a natural flavonoid known for its antioxidant, anti-inflammatory, and antiproliferative effects on animals. In this work, we have studied the effect of this compound on rainbow trout, , a major object of aquaculture, under slowly increasing ambient temperature and flatworm infection. Tr...

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Bibliographic Details
Published in:Animals (Basel) 2022-05, Vol.12 (10), p.1321
Main Authors: Sukhovskaya, Irina V, Kantserova, Nadezhda P, Lysenko, Liudmila A, Morozov, Alexey A
Format: Article
Language:English
Subjects:
Ambient temperature
Antioxidants
Apoptosis
Aquaculture
Biosynthesis
Cadmium
Cell cycle
Cell death
Cholesterol
Cytochrome
Diet
Enzymes
Feed supplements
Fish
Fish diets
Fish parasites
Fish populations
Flavonoids
Gyrodactylus
Gyrodactylus sp
Heat
Heat shock proteins
Heat stress
Heat tolerance
Heat treatment
Heat treatments
High temperature
Infections
Inflammation
Isopentenyl diphosphate
Lipids
liver
Metabolism
Nitrogen
Oncorhynchus mykiss
Parasites
Physiology
Proteins
rainbow trout
Salmon
Statistical analysis
Statistical methods
Sterols
taxifolin
Temperature dependence
transcriptome
Transcriptomics
Trout
Tumor necrosis factor-TNF
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Summary:Taxifolin is a natural flavonoid known for its antioxidant, anti-inflammatory, and antiproliferative effects on animals. In this work, we have studied the effect of this compound on rainbow trout, , a major object of aquaculture, under slowly increasing ambient temperature and flatworm infection. Transcriptomic profiling of liver samples performed by using the Illumina HiSeq 2500 sequencing platform shows that a combined taxifolin/heat treatment, unlike heat treatment alone, downregulates the production of isopentenyl diphosphate, likely affecting the production of cholesterol and other sterols. Taxifolin treatment also modulates multiple apoptosis regulators and affects the expression of HSPs in response to increasing temperature. On the other hand, the expression of antioxidant enzymes in response to heat is not significantly affected by taxifolin. As for the infection, the parasite load is not affected by taxifolin treatment, although it was lower in the high-temperature group. Parasite load also did not induce a statistically significant transcriptomic response within the no heat/no taxifolin group.
ISSN:2076-2615
2076-2615
DOI:10.3390/ani12101321