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Taxifolin Modulates Transcriptomic Response to Heat Stress in Rainbow Trout, Oncorhynchus mykiss
Taxifolin is a natural flavonoid known for its antioxidant, anti-inflammatory, and antiproliferative effects on animals. In this work, we have studied the effect of this compound on rainbow trout, , a major object of aquaculture, under slowly increasing ambient temperature and flatworm infection. Tr...
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| Published in: | Animals (Basel) 2022-05, Vol.12 (10), p.1321 |
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| creator | Sukhovskaya, Irina V Kantserova, Nadezhda P Lysenko, Liudmila A Morozov, Alexey A |
| description | Taxifolin is a natural flavonoid known for its antioxidant, anti-inflammatory, and antiproliferative effects on animals. In this work, we have studied the effect of this compound on rainbow trout,
, a major object of aquaculture, under slowly increasing ambient temperature and
flatworm infection. Transcriptomic profiling of liver samples performed by using the Illumina HiSeq 2500 sequencing platform shows that a combined taxifolin/heat treatment, unlike heat treatment alone, downregulates the production of isopentenyl diphosphate, likely affecting the production of cholesterol and other sterols. Taxifolin treatment also modulates multiple apoptosis regulators and affects the expression of HSPs in response to increasing temperature. On the other hand, the expression of antioxidant enzymes in response to heat is not significantly affected by taxifolin. As for the
infection, the parasite load is not affected by taxifolin treatment, although it was lower in the high-temperature group. Parasite load also did not induce a statistically significant transcriptomic response within the no heat/no taxifolin group. |
| doi_str_mv | 10.3390/ani12101321 |
| format | article |
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, a major object of aquaculture, under slowly increasing ambient temperature and
flatworm infection. Transcriptomic profiling of liver samples performed by using the Illumina HiSeq 2500 sequencing platform shows that a combined taxifolin/heat treatment, unlike heat treatment alone, downregulates the production of isopentenyl diphosphate, likely affecting the production of cholesterol and other sterols. Taxifolin treatment also modulates multiple apoptosis regulators and affects the expression of HSPs in response to increasing temperature. On the other hand, the expression of antioxidant enzymes in response to heat is not significantly affected by taxifolin. As for the
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, a major object of aquaculture, under slowly increasing ambient temperature and
flatworm infection. Transcriptomic profiling of liver samples performed by using the Illumina HiSeq 2500 sequencing platform shows that a combined taxifolin/heat treatment, unlike heat treatment alone, downregulates the production of isopentenyl diphosphate, likely affecting the production of cholesterol and other sterols. Taxifolin treatment also modulates multiple apoptosis regulators and affects the expression of HSPs in response to increasing temperature. On the other hand, the expression of antioxidant enzymes in response to heat is not significantly affected by taxifolin. As for the
infection, the parasite load is not affected by taxifolin treatment, although it was lower in the high-temperature group. Parasite load also did not induce a statistically significant transcriptomic response within the no heat/no taxifolin group.</description><subject>Ambient temperature</subject><subject>Antioxidants</subject><subject>Apoptosis</subject><subject>Aquaculture</subject><subject>Biosynthesis</subject><subject>Cadmium</subject><subject>Cell cycle</subject><subject>Cell death</subject><subject>Cholesterol</subject><subject>Cytochrome</subject><subject>Diet</subject><subject>Enzymes</subject><subject>Feed supplements</subject><subject>Fish</subject><subject>Fish diets</subject><subject>Fish parasites</subject><subject>Fish populations</subject><subject>Flavonoids</subject><subject>Gyrodactylus</subject><subject>Gyrodactylus sp</subject><subject>Heat</subject><subject>Heat shock proteins</subject><subject>Heat stress</subject><subject>Heat tolerance</subject><subject>Heat treatment</subject><subject>Heat treatments</subject><subject>High temperature</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Isopentenyl diphosphate</subject><subject>Lipids</subject><subject>liver</subject><subject>Metabolism</subject><subject>Nitrogen</subject><subject>Oncorhynchus mykiss</subject><subject>Parasites</subject><subject>Physiology</subject><subject>Proteins</subject><subject>rainbow trout</subject><subject>Salmon</subject><subject>Statistical analysis</subject><subject>Statistical methods</subject><subject>Sterols</subject><subject>taxifolin</subject><subject>Temperature dependence</subject><subject>transcriptome</subject><subject>Transcriptomics</subject><subject>Trout</subject><subject>Tumor necrosis factor-TNF</subject><issn>2076-2615</issn><issn>2076-2615</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdkkFv1DAQhS1ERattT9xRJC5IsGXGdmL7goQqoJVaVSrL2TiO0_WS2Fs7od1_T5Yt1Za5eDT-5unZM4S8RjhlTMFHEzxSBGQUX5AjCqKa0wrLl3v5ITnJeQVTiJJhia_IISsrWmIljsjPhXnwbex8KK5iM3ZmcLlYJBOyTX49xN7b4sbldQzZFUMszp0Ziu9DcjkXU8-N8aGO91NHHIcPxXWwMS03wS7HXPSbXz7nY3LQmi67k8dzRn58_bI4O59fXn-7OPt8ObeMAs5t0ypEYRg4plAw2UhphDKOV61UhnLVKsoaqVpgHGoqLG9Q8cbRUkFdMjYjFzvdJpqVXiffm7TR0Xj9txDTrTZp8LZzuhRWNTUDabnjHIVUACgALJegjDST1qed1nqse9dYF4Zkumeiz2-CX-rb-FsrZEJO7mfk3aNAinejy4Pufbau60xwccyaVgKpwO3cZuTtf-gqjilMX7WlAEo-vXCi3u8om2LOybVPZhD0dhH03iJM9Jt9_0_sv7GzPwmZrQE</recordid><startdate>20220522</startdate><enddate>20220522</enddate><creator>Sukhovskaya, Irina V</creator><creator>Kantserova, Nadezhda P</creator><creator>Lysenko, Liudmila A</creator><creator>Morozov, Alexey A</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-5844-4788</orcidid><orcidid>https://orcid.org/0000-0002-9558-7400</orcidid></search><sort><creationdate>20220522</creationdate><title>Taxifolin Modulates Transcriptomic Response to Heat Stress in Rainbow Trout, Oncorhynchus mykiss</title><author>Sukhovskaya, Irina V ; Kantserova, Nadezhda P ; Lysenko, Liudmila A ; Morozov, Alexey A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3201-cdf9117a30e391738d88a79ae46f89a249f923d89f0340b27c4d194de2590b533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Ambient temperature</topic><topic>Antioxidants</topic><topic>Apoptosis</topic><topic>Aquaculture</topic><topic>Biosynthesis</topic><topic>Cadmium</topic><topic>Cell cycle</topic><topic>Cell death</topic><topic>Cholesterol</topic><topic>Cytochrome</topic><topic>Diet</topic><topic>Enzymes</topic><topic>Feed supplements</topic><topic>Fish</topic><topic>Fish diets</topic><topic>Fish parasites</topic><topic>Fish populations</topic><topic>Flavonoids</topic><topic>Gyrodactylus</topic><topic>Gyrodactylus sp</topic><topic>Heat</topic><topic>Heat shock proteins</topic><topic>Heat stress</topic><topic>Heat tolerance</topic><topic>Heat treatment</topic><topic>Heat treatments</topic><topic>High temperature</topic><topic>Infections</topic><topic>Inflammation</topic><topic>Isopentenyl diphosphate</topic><topic>Lipids</topic><topic>liver</topic><topic>Metabolism</topic><topic>Nitrogen</topic><topic>Oncorhynchus mykiss</topic><topic>Parasites</topic><topic>Physiology</topic><topic>Proteins</topic><topic>rainbow trout</topic><topic>Salmon</topic><topic>Statistical analysis</topic><topic>Statistical methods</topic><topic>Sterols</topic><topic>taxifolin</topic><topic>Temperature dependence</topic><topic>transcriptome</topic><topic>Transcriptomics</topic><topic>Trout</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sukhovskaya, Irina V</creatorcontrib><creatorcontrib>Kantserova, Nadezhda P</creatorcontrib><creatorcontrib>Lysenko, Liudmila A</creatorcontrib><creatorcontrib>Morozov, Alexey A</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Animals (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sukhovskaya, Irina V</au><au>Kantserova, Nadezhda P</au><au>Lysenko, Liudmila A</au><au>Morozov, Alexey A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Taxifolin Modulates Transcriptomic Response to Heat Stress in Rainbow Trout, Oncorhynchus mykiss</atitle><jtitle>Animals (Basel)</jtitle><addtitle>Animals (Basel)</addtitle><date>2022-05-22</date><risdate>2022</risdate><volume>12</volume><issue>10</issue><spage>1321</spage><pages>1321-</pages><issn>2076-2615</issn><eissn>2076-2615</eissn><abstract>Taxifolin is a natural flavonoid known for its antioxidant, anti-inflammatory, and antiproliferative effects on animals. In this work, we have studied the effect of this compound on rainbow trout,
, a major object of aquaculture, under slowly increasing ambient temperature and
flatworm infection. Transcriptomic profiling of liver samples performed by using the Illumina HiSeq 2500 sequencing platform shows that a combined taxifolin/heat treatment, unlike heat treatment alone, downregulates the production of isopentenyl diphosphate, likely affecting the production of cholesterol and other sterols. Taxifolin treatment also modulates multiple apoptosis regulators and affects the expression of HSPs in response to increasing temperature. On the other hand, the expression of antioxidant enzymes in response to heat is not significantly affected by taxifolin. As for the
infection, the parasite load is not affected by taxifolin treatment, although it was lower in the high-temperature group. Parasite load also did not induce a statistically significant transcriptomic response within the no heat/no taxifolin group.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>35625167</pmid><doi>10.3390/ani12101321</doi><orcidid>https://orcid.org/0000-0001-5844-4788</orcidid><orcidid>https://orcid.org/0000-0002-9558-7400</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Ambient temperature Antioxidants Apoptosis Aquaculture Biosynthesis Cadmium Cell cycle Cell death Cholesterol Cytochrome Diet Enzymes Feed supplements Fish Fish diets Fish parasites Fish populations Flavonoids Gyrodactylus Gyrodactylus sp Heat Heat shock proteins Heat stress Heat tolerance Heat treatment Heat treatments High temperature Infections Inflammation Isopentenyl diphosphate Lipids liver Metabolism Nitrogen Oncorhynchus mykiss Parasites Physiology Proteins rainbow trout Salmon Statistical analysis Statistical methods Sterols taxifolin Temperature dependence transcriptome Transcriptomics Trout Tumor necrosis factor-TNF |
| title | Taxifolin Modulates Transcriptomic Response to Heat Stress in Rainbow Trout, Oncorhynchus mykiss |
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