Acute exercise inhibits gastric emptying of liquids in rats: influence of the NO-cGMP pathway

We previously found that acute exercise inhibited the gastric emptying of liquid in awake rats by causing an acid-base imbalance. In the present study, we investigated the involvement of the nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathway, vasoactive intestinal peptide (VIP), and corti...

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Published in:Brazilian journal of medical and biological research 2018-01, Vol.51 (11), p.e7541-e7541
Main Authors: Cavalcante, A K M, Siqueira, R C L, Feitosa Júnior, V N, de Andrade, C R, Santos, A A, Silva, M T B
Format: Article
Language:English
Subjects:
Acute exercise
Arginine
Atropine
Bioelectrical impedance
BIOLOGY
Colon
Corticosterone
Corticotropin-releasing hormone
Cyclic GMP
Gastric emptying
Gastric motility
Guanosine
High-intensity exercise
Intestine
Lactic acid
MEDICINE, RESEARCH & EXPERIMENTAL
NG-Nitroarginine methyl ester
Nitric oxide
Nitric-oxide synthase
Peptides
Rodents
Sodium chloride
Vasoactive agents
Vasoactive intestinal peptide
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Summary:We previously found that acute exercise inhibited the gastric emptying of liquid in awake rats by causing an acid-base imbalance. In the present study, we investigated the involvement of the nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathway, vasoactive intestinal peptide (VIP), and corticotropin-releasing factor (CRF) peptide in this phenomenon. Male rats were divided into exercise or sedentary group and were subjected to a 15-min swim session against a load (2.5 or 5% b.w.). The rate of gastric emptying was evaluated after 5, 10, or 20 min postprandially. Separate groups of rats were treated with vehicle (0.9% NaCl, 0.1 mL/100 g, ip) or one of the following agents: atropine (1.0 mg/kg, ip), the NO non-selective inhibitor Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME; 10.0 mg/kg, ip), or the selective cGMP inhibitor 1H-(1,2,4)oxadiazole[4,3-a]quinoxalin-1-one (ODQ; 5.0 mg/kg, ip), the i-NOS non-specific inhibitor (aminoguanidine; 10.0 mg/kg, ip), the corticotropin-releasing factor receptor antagonist (astressin; 100 µg/kg, ip), or the vasoactive intestinal peptide (VIP) receptor antagonist Lys1, Pro2,5, Arg3,4, Tyr6 (100 µg/kg, ip). Compared to sedentary rats, both the 2.5 and 5% exercise groups exhibited higher (P
ISSN:0100-879X
1414-431X
1414-431X
1678-4510
DOI:10.1590/1414-431X20187541