Regional brain activity and connectivity associated with childhood trauma in drug-naive patients with obsessive–compulsive disorder

Obsessive–compulsive disorder (OCD) is characterized by intrusive thoughts and repetitive, compulsive behaviors, with childhood trauma recognized as a contributing factor to its pathophysiology. This study aimed to delineate brain functional aberrations in OCD patients and explore the association be...

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Bibliographic Details
Published in:Scientific reports 2024-08, Vol.14 (1), p.18111-12, Article 18111
Main Authors: Zhang, Manxue, Wu, Chujun, Lu, Shihao, Wang, Yanrong, Ma, Rui, Du, Yunyun, Wang, Shaoxia, Fang, Jianqun
Format: Article
Language:English
Subjects:
631/378/1689/4032
631/477/2811
692/699/476/4032
Adult
Amplitude of low-frequency fluctuation
Brain - diagnostic imaging
Brain - physiopathology
Brain Mapping
Case-Control Studies
Cerebellum
Cerebellum - diagnostic imaging
Cerebellum - physiopathology
Childhood
Childhood trauma
Children
Drug addiction
Emotional abuse
Emotions
Female
Functional magnetic resonance imaging
Humanities and Social Sciences
Humans
Magnetic Resonance Imaging
Male
multidisciplinary
Neural networks
Neuroimaging
Obsessive compulsive disorder
Obsessive-Compulsive Disorder - diagnostic imaging
Obsessive-Compulsive Disorder - physiopathology
Patients
Regional homogeneity
Resting-state functional connectivity
Science
Science (multidisciplinary)
Trauma
Traumatic brain injury
Young Adult
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Summary:Obsessive–compulsive disorder (OCD) is characterized by intrusive thoughts and repetitive, compulsive behaviors, with childhood trauma recognized as a contributing factor to its pathophysiology. This study aimed to delineate brain functional aberrations in OCD patients and explore the association between these abnormalities and childhood trauma, to gain insights into the neural underpinnings of OCD. Forty-eight drug-naive OCD patients and forty-two healthy controls (HC) underwent resting-state functional magnetic resonance imaging and clinical assessments, including the Yale–Brown Obsessive Compulsive Scale (Y–BOCS) and Childhood Trauma Questionnaire-Short Form (CTQ-SF). Compared to HCs, OCD patients exhibited significantly decreased amplitude of low-frequency fluctuations (ALFF) in the right cerebellum, decreased regional homogeneity (ReHo) in the right cerebellum and right superior occipital lobes (FWE-corrected p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-69122-y