Preparation of Functional Nanoparticles-Loaded Magnetic Carbon Nanohorn Nanocomposites towards Composite Treatment

Combination therapy for cancer is expected for the synergetic effect of different treatments, and the development of promising carrier materials is demanded for new therapeutics. In this study, nanocomposites including functional nanoparticles (NPs) such as samarium oxide NP for radiotherapy and gad...

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Published in:Nanomaterials (Basel, Switzerland) Switzerland), 2023-02, Vol.13 (5), p.839
Main Authors: Rahmania, Fitriani Jati, Huang, Yi-Shou, Workie, Yitayal Admassu, Imae, Toyoko, Kondo, Anna, Miki, Yukiko, Imai, Ritsuko, Nagai, Takashi, Nakagawa, Hiroshi, Kawai, Noriyasu, Tsutsumiuchi, Kaname
Format: Article
Language:English
Subjects:
Antitumor agents
Camptothecin
Cancer
Cancer therapies
Carbon
carbon nanohorn
Care and treatment
Chemotherapy
Doxorubicin
drug co-delivery
Drug delivery
Drug delivery systems
Drugs
Ferric oxide
Gadolinium
Gadolinium oxide
Gadolinium oxides
Gemcitabine
Graphene
Health aspects
Hyperthermia
Iron compounds
iron oxide
Iron oxides
Magnetic resonance imaging
Nanocomposites
Nanoparticles
Nanotubes
Nitrates
Polyethylene glycol
Quantum dots
Radiation therapy
Radiotherapy
Reagents
Samarium
samarium oxide
Thermotherapy
Vehicles
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Summary:Combination therapy for cancer is expected for the synergetic effect of different treatments, and the development of promising carrier materials is demanded for new therapeutics. In this study, nanocomposites including functional nanoparticles (NPs) such as samarium oxide NP for radiotherapy and gadolinium oxide NP as a magnetic resonance imaging agent were synthesized and chemically combined with iron oxide NP-embedded or carbon dot-coating iron oxide NP-embedded carbon nanohorn carriers, where iron oxide NP is a hyperthermia reagent and carbon dot exerts effects on photodynamic/photothermal treatments. These nanocomposites exerted potential for delivery of anticancer drugs (doxorubicin, gemcitabine, and camptothecin) even after being coated with poly(ethylene glycol). The co-delivery of these anticancer drugs played better drug-release efficacy than the independent drug delivery, and the thermal and photothermal procedures enlarged the drug release. Thus, the prepared nanocomposites can be expected as materials to develop advanced medication for combination treatment.
ISSN:2079-4991
2079-4991
DOI:10.3390/nano13050839