Comparison of C-Reactive Protein and Serum Amyloid A Protein in Septic Shock Patients

Septic shock is a severe inflammatory state caused by an infectious agent. Our purpose was to investigate serum amyloid A (SAA) protein and C-reactive protein (CRP) as inflammatory markers of septic shock patients. Here we evaluate 29 patients in postoperative period, with septic shock, in a prospec...

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Bibliographic Details
Published in:Mediators of Inflammation 2008-01, Vol.2008 (2008), p.271-275
Main Authors: Cicarelli, Domingos Dias, Vieira, Joaquim Edson, Benseñor, Fábio Ely Martins
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
C-Reactive Protein - metabolism
Female
General aspects
Humans
Intensive Care Units
Male
Medical sciences
Middle Aged
Multiple Organ Failure - blood
Multiple Organ Failure - diagnosis
Postoperative Care - methods
Predictive Value of Tests
Prospective Studies
Serum Amyloid A Protein - metabolism
Shock, Septic - blood
Shock, Septic - diagnosis
Shock, Septic - mortality
Survival Rate
Time Factors
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Summary:Septic shock is a severe inflammatory state caused by an infectious agent. Our purpose was to investigate serum amyloid A (SAA) protein and C-reactive protein (CRP) as inflammatory markers of septic shock patients. Here we evaluate 29 patients in postoperative period, with septic shock, in a prospective study developed in a surgical intensive care unit. All eligible patients were monitored over a 7-day period by sequential organ failure assessment (SOFA) score, daily CRP, SAA, and lactate measurements. CRP and SAA strongly correlated up to the fifth day of observation but were not good predictors of mortality in septic shock.
ISSN:0962-9351
1466-1861
DOI:10.1155/2008/631414