Effectiveness and safety of weekly therapy versus 3-weekly therapy of paclitaxel plus carboplatin in women with ovarian cancer: a protocol of systematic review and meta-analysis

IntroductionNetwork meta-analyses have confirmed that paclitaxel plus carboplatin could improve progression-free survival (PFS) and overall survival (OS) compared with platinum alone. However, detailed implementation schedule (weekly or 3-weekly therapy) was not specified in clinical practice guidel...

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Bibliographic Details
Published in:BMJ open 2022-03, Vol.12 (3), p.e053182-e053182
Main Authors: Qiu, Weitao, Fu, Yu, Dang, Yun, Cai, Bingxin, Tuo, Shumei, Mao, Baohong, Lin, Ru, Liu, Qing, Li, Yilin
Format: Article
Language:English
Subjects:
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Bias
Cancer therapies
Carboplatin - therapeutic use
Carcinoma, Ovarian Epithelial
Chemotherapy
Clinical practice guidelines
Drug dosages
Female
gynaecological oncology
gynaecology
Humans
Intervention
Meta-analysis
Meta-Analysis as Topic
Oncology
Ovarian cancer
Ovarian Neoplasms
Paclitaxel - adverse effects
Patients
Performance evaluation
Sensitivity analysis
Software
Surgery
Systematic review
Systematic Reviews as Topic
Womens health
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Summary:IntroductionNetwork meta-analyses have confirmed that paclitaxel plus carboplatin could improve progression-free survival (PFS) and overall survival (OS) compared with platinum alone. However, detailed implementation schedule (weekly or 3-weekly therapy) was not specified in clinical practice guidelines. Evidence from studies is also inconsistent. We will conduct a systematic review and meta-analysis to evaluate the benefits and harms of weekly therapy and 3-weekly therapy of paclitaxel combined with carboplatin in women with ovarian cancer.MethodsWe will search PubMed, EMBASE and the Cochrane Library databases to include relevant randomised controlled trials comparing weekly therapy versus 3-weekly therapy of paclitaxel combined with carboplatin for women with ovarian cancer. Random-effects model will be used to pool data for patient-reported outcomes including survival rate, OS, PFS and adverse events. Grading of Recommendation, Assessment, Development and Evaluation approach will be used to rate the quality of evidence.Ethics and disseminationThis systematic review and meta-analysis will be based on published data and does not therefore require specific ethical approval or consent for participation. The results will be published in a peer-reviewed journal.OSF registration number10.17605/OSF.IO/GJUMA.
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2021-053182