Efficacy of a chairside diagnostic test kit for estimation of C-reactive protein levels in periodontal disease

C-reactive protein [CRP] levels increase to hundreds of mg/mL within hours following infection. Studies have shown that serum CRP levels were elevated in periodontal disease. However, in all the previous studies, CRP levels were measured by using high-sensitivity CRP assay kits with minimal detectio...

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Bibliographic Details
Published in:Journal of Indian Society of Periodontology 2010-10, Vol.14 (4), p.213-216
Main Authors: Nagarale, Girish, Ravindra, S, Thakur, Srinath, Setty, Swati
Format: Article
Language:English
Subjects:
Antibiotics
Bacterial infections
C-reactive protein
chair-side diagnostic kit
Diagnosis
Diagnostic tests
Gum disease
Medical testing products
Methods
Original
Periodontal disease
Physiological aspects
Proteins
Standard deviation
Studies
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Summary:C-reactive protein [CRP] levels increase to hundreds of mg/mL within hours following infection. Studies have shown that serum CRP levels were elevated in periodontal disease. However, in all the previous studies, CRP levels were measured by using high-sensitivity CRP assay kits with minimal detection limits of 0.1 to 3 mg/L, which was much below the normal value of 10 mg/L. These high-sensitivity CRP assays need a proper laboratory setup, and these methods cannot be used as a routine chair-side test in the dental office. The purpose of this study was to investigate the serum CRP levels in subjects with periodontal disease by using a rapid chair-side diagnostic test kit with a lower detection limit of 6 mg/L and to compare the CRP levels before and after periodontal therapy. A total of 45 systemically healthy subjects were selected for the study. Subjects were divided into three groups: group A: healthy controls, group B: gingivitis, group C: periodontitis. Serum levels of CRP were determined by using a latex slide agglutination method with commercially available kit with lower detection limit of 6 mg/L. CRP was negative in all the 15 subjects in groups A and B at baseline, 7th and 30th day. CRP was positive only in 2 subjects in Group C at baseline and 7th day. Estimation of serum CRP by using a rapid chair-side diagnostic test kit is not of any significance in subjects with periodontitis.
ISSN:0972-124X
0975-1580
DOI:10.4103/0972-124X.76919