Inflammation, HIF-1, and the Epigenetics That Follows

We summarize recent findings linking inflammatory hypoxia to chromatin modifications, in particular to repressive histone signatures. We focus on the role of Hypoxia-Induced Factor-1 in promoting the activity of specific histone demethylases thus deeply modifying chromatin configuration. The consequ...

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Bibliographic Details
Published in:Mediators of Inflammation 2010-01, Vol.2010 (2010), p.228-232
Main Authors: Brigati, Claudio, Banelli, Barbara, di Vinci, Angela, Casciano, Ida, Allemanni, Giorgio, Forlani, Alessandra, Borzì, Luana, Romani, Massimo
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Development and progression
Epigenesis, Genetic
General aspects
Genetic aspects
Health aspects
Histone Demethylases - metabolism
Histones
Histones - genetics
Histones - metabolism
Humans
Hypoxia - genetics
Hypoxia - metabolism
Hypoxia-Inducible Factor 1 - biosynthesis
Hypoxia-Inducible Factor 1 - genetics
Inflammation
Inflammation - genetics
Inflammation - metabolism
Medical sciences
Review
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Summary:We summarize recent findings linking inflammatory hypoxia to chromatin modifications, in particular to repressive histone signatures. We focus on the role of Hypoxia-Induced Factor-1 in promoting the activity of specific histone demethylases thus deeply modifying chromatin configuration. The consequences of these changes are depicted in terms of gene expression and cellular phenotypes. We finally integrate available data to introduce novel speculations on the relationship between inflammation, histones, and DNA function and integrity.
ISSN:0962-9351
1466-1861
DOI:10.1155/2010/263914