In Vitro Evaluation of Antiprotozoal and Antiviral Activities of Extracts from Argentinean Mikania Species

The aim of this study was to investigate the antiprotozoal and antiviral activities of four Argentinean Mikania species. The organic and aqueous extracts of Mikania micrantha, M. parodii, M. periplocifolia, and M. cordifolia were tested on Trypanosoma cruzi epimastigotes, Leishmania braziliensis pro...

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Published in:TheScientificWorld 2012-01, Vol.2012 (2012), p.1-6
Main Authors: Cazorla, Silvia I., Malchiodi, Emilio, Martino, Virginia S., Sülsen, Valeria P., Laurella, Laura C., Catalán, César A. N., Cavallaro, Lucía, Giberti, Gustavo, Frank, Fernanda M., Sarquiz, Andrea, Alonso, María R.
Format: Article
Language:English
Subjects:
Antiprotozoal Agents - pharmacology
Antiviral Agents - pharmacology
Asteraceae
Biology
Chromatography
Chromatography, High Pressure Liquid
Dengue fever
Dengue Virus - drug effects
Dengue virus type 2
Epidemics
Epimastigotes
Fractionation
In Vitro Techniques
Infections
Infrared analysis
Lactones
Leishmania
Leishmania braziliensis
Leishmania braziliensis - drug effects
Mikania
Mikania - chemistry
Mikania micrantha
Natural products
Parasitic diseases
Pharmaceutical industry
Plant Extracts - pharmacology
Promastigotes
Protozoa
Sesquiterpene lactones
Spectroscopy, Fourier Transform Infrared
Tropical diseases
Trypanosoma cruzi
Trypanosoma cruzi - drug effects
Vector-borne diseases
Viral diseases
Viral infections
Viruses
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Summary:The aim of this study was to investigate the antiprotozoal and antiviral activities of four Argentinean Mikania species. The organic and aqueous extracts of Mikania micrantha, M. parodii, M. periplocifolia, and M. cordifolia were tested on Trypanosoma cruzi epimastigotes, Leishmania braziliensis promastigotes, and dengue virus type 2. The organic extract of M. micrantha was the most active against T. cruzi and L. braziliensis exhibiting a growth inhibition of 77.6±4.5% and 84.9±6.1%, respectively, at a concentration of 10 μg/ml. The bioguided fractionation of M. micrantha organic extract led to the identification of two active fractions. The chromatographic profile and infrared analysis of these fractions revealed the presence of sesquiterpene lactones. None of the tested extracts were active against dengue virus type 2.
ISSN:2356-6140
1537-744X
1537-744X
DOI:10.1100/2012/121253