Δ 9-Tetrahydrocannabinol Toxicity and Validation of Cannabidiol on Brain Dopamine Levels: An Assessment on Cannabis Duplicity

Δ9-tetrahydrocannabinol (THC) of cannabis is the main psychoactive component which is a global significant concern to human health. Evaluation on THC reported its drastic effect on the brain dopaminergic (DAergic) system stimulating mesolimbic DA containing neurons thereby increasing the level of st...

Full description

Saved in:
Bibliographic Details
Published in:Natural products and bioprospecting 2020-10, Vol.10 (5), p.285-296
Main Authors: Chetia, Swapnali, Borah, Gaurab
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Bioorganic Chemistry
Cannabidiol
Cannabis
Dopamine
Food Science
Life Sciences
Medicinal Chemistry
Medicinal uses
Pharmacology/Toxicology
Plant Biochemistry
Plant Sciences
Review
Tetrahydrocannabinol
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Δ9-tetrahydrocannabinol (THC) of cannabis is the main psychoactive component which is a global significant concern to human health. Evaluation on THC reported its drastic effect on the brain dopaminergic (DAergic) system stimulating mesolimbic DA containing neurons thereby increasing the level of striatal DA. Cannabidiol (CBD), with its anxiolytic and anti-psychotic property, is potent to ameliorate the THC-induced DAergic variations. Legal authorization of cannabis use and its analogs in most countries led to a drastic dispute in the elicitation of cannabis products. With a recent increase in cannabis-induced disorder rates, the present review highlighted the detrimental effects of THC and the effects of CBD on THC induced alterations in DA synthesis and release. Alongside the reported data, uses of cannabis as a therapeutic medium in a number of health complications are also being briefly reviewed. These evaluated reports led to an anticipation of additional research contradictory to the findings of THC and CBD activity in the brain DAergic system and their medical implementations as therapeutics. Graphic Abstract
ISSN:2192-2195
2192-2209
DOI:10.1007/s13659-020-00263-z