2204 Characterizing specialized pro-resolving lipid mediators and synthesis pathways in veterans with peripheral artery disease

OBJECTIVES/SPECIFIC AIMS: Specialized pro-resolving lipid mediators (SPM) actively counter proinflammatory cascades. A deficit of SPMs is one possible mechanism through which inflammation leads to the development of atherosclerotic disease. The purpose of this study is to characterize the profiles o...

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Bibliographic Details
Published in:Journal of clinical and translational science 2018-06, Vol.2 (S1), p.6-7
Main Authors: Ramirez, Joel, Zahner, Greg J., Khetani, Sukaynah A., Spaulding, Kimberly A., Hills, Nancy K., Grenon, S. Marlene
Format: Article
Language:English
Subjects:
Ankle
Arteriosclerosis
Basic/Translational Science/Team Science
Cardiovascular disease
Cardiovascular diseases
Coronary artery
Diabetes mellitus
Eicosapentaenoic acid
Heart diseases
Hyperlipidemia
Immunosuppression
Intermediates
Ischemia
Liquid chromatography
Mass spectroscopy
Patients
Population studies
Surgery
Vascular diseases
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Summary:OBJECTIVES/SPECIFIC AIMS: Specialized pro-resolving lipid mediators (SPM) actively counter proinflammatory cascades. A deficit of SPMs is one possible mechanism through which inflammation leads to the development of atherosclerotic disease. The purpose of this study is to characterize the profiles of intermediates of SPM synthesis pathways and end-product SPMs in the plasma of patients with peripheral artery disease (PAD). METHODS/STUDY POPULATION: A cross-sectional sample of 52 patients with PAD was recruited at the San Francisco Veterans Affairs Medical Center. PAD was defined as the presence of claudication symptoms and an ankle-brachial index
ISSN:2059-8661
2059-8661
DOI:10.1017/cts.2018.53