Serum Folate, Red Blood Cell Folate, and Zinc Serum Levels Are Related with Gestational Weight Gain and Offspring's Birth-Weight of Adolescent Mothers

• Published in: Nutrients 2024-05, Vol.16 (11), p.1632
• Main Authors: Sámano, Reyna, Martínez-Rojano, Hugo, Chico-Barba, Gabriela, Gamboa, Ricardo, Tolentino, Maricruz, Toledo-Barrera, Alexa Xiomara, Ramírez-González, Cristina, Mendoza-Flores, María Eugenia, Hernández-Trejo, María, Godínez-Martínez, Estela
• Format: Article
• Language: English
• Subjects: Adolescent; Adults; Anemia; Birth defects; Birth Weight; Blood; Body mass index; Cell division; Developing countries; Dietary supplements; Disease susceptibility; Eating behavior; Erythrocytes; Female; folate; Folic acid; Folic Acid - blood; Gestational Weight Gain; Hemoglobin; Humans; Hypertension; Infant, Newborn; Infant, Small for Gestational Age - blood; Infants (Newborn); Iron; LDCs; maternal diet; Mexico; newborn small for gestational age; Nutrition; Nutritional status; Pregnancy; Pregnancy complications; Pregnancy in Adolescence - blood; Prenatal care; Protein synthesis; Teenage parents; teenage pregnancy; Teenagers; Vitamin B; Womens health; Youth; Zinc; Zinc - blood; Zinc - deficiency; Zinc in the body
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu16111632

Gestational weight gain below or above the Institute of Medicine recommendations has been associated with adverse perinatal and neonatal outcomes. Very few studies have evaluated the association between serum and red blood cell folate concentrations and gestational weight gain in adolescents. Additionally, zinc deficiency during pregnancy has been associated with impaired immunity, prolonged labor, preterm and post-term birth, intrauterine growth restriction, low birth weight, and pregnancy-induced hypertension. The purpose of our study is to evaluate the association between serum concentrations of zinc, serum folate, and red blood cell folate, with the increase in gestational weight and the weight and length of the newborn in a group of adolescent mothers from Mexico City. In our study, 406 adolescent-neonate dyads participated. The adolescents' median age was 15.8 years old. The predominant socioeconomic level was middle-low (57.8%), single (57%), 89.9% were engaged in home activities, and 41.3% completed secondary education. Excessive gestational weight gain was observed in 36.7% of cases, while insufficient gestational weight gain was noted in 38.4%. Small for gestational age infants were observed in 20.9% of the sample. Low serum folate (OR 2.1, 95% CI 1.3-3.3), decreased red blood cell folate (OR 1.6, 95% CI 1.0-2.6), and reduced serum zinc concentrations (OR 3.3, 95% CI 2.1-5.2) were associated with insufficient gestational weight gain. Decreased serum zinc levels (OR 1.2, 95% CI 1.2-3.4) were linked to an increased probability of delivering a baby who is small for their gestational age. Low serum folate, red blood cell folate, and serum zinc concentrations were associated with gestational weight gain and having a small gestational age baby. Both excessive and insufficient gestational weight gain, as well as having a small gestational age baby, are frequent among adolescent mothers.