The tigecycline resistance mechanisms in Gram-negative bacilli

Tigecycline, hailed as a pivotal agent in combating multidrug-resistant bacterial infections, confronts obstacles posed by the emergence of resistance mechanisms in Gram-negative bacilli. This study explores the complex mechanisms of tigecycline resistance in Gram-negative bacilli, with a particular...

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Bibliographic Details
Published in:Frontiers in cellular and infection microbiology 2024-11, Vol.14, p.1471469
Main Authors: Wang, Zhiren, Li, Henan
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Bacterial Proteins - metabolism
Cellular and Infection Microbiology
Drug Resistance, Multiple, Bacterial
Gram-negative bacilli
Gram-Negative Bacteria - drug effects
Gram-Negative Bacteria - physiology
Gram-Negative Bacterial Infections - drug therapy
Gram-Negative Bacterial Infections - microbiology
Humans
Membrane Transport Proteins - metabolism
Microbial Sensitivity Tests
resistance mechanism
resistance regulation
tigecycline
Tigecycline - pharmacology
Tigecycline - therapeutic use
tigecycline resistance
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Summary:Tigecycline, hailed as a pivotal agent in combating multidrug-resistant bacterial infections, confronts obstacles posed by the emergence of resistance mechanisms in Gram-negative bacilli. This study explores the complex mechanisms of tigecycline resistance in Gram-negative bacilli, with a particular focus on the role of efflux pumps and drug modification in resistance. By summarizing these mechanisms, our objective is to provide a comprehensive understanding of tigecycline resistance in Gram-negative bacilli, thereby illuminating the evolving landscape of antimicrobial resistance. This review contributes to the elucidation of current existing tigecycline resistance mechanisms and provides insights into the development of effective strategies to manage the control of antimicrobial resistance in the clinical setting, as well as potential new targets for the treatment of tigecycline-resistant bacterial infections.
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2024.1471469