Up-Regulation of FOXC2 and FOXQ1 Is Associated with The Progression of Gastric-Type Adenocarcinoma

Forkhead box (FOX) proteins are important regulators of the epithelial-to-mesenchymal transition (EMT), which is the main mechanism of cancer metastasis. Different studies have shown their potential involvement in progression of cancer in different tissues such as breast, ovary and colorectum. In th...

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Bibliographic Details
Published in:Cell journal (Yakhteh) 2017-01, Vol.19 (Suppl 1), p.66-71
Main Authors: Soleimani, Farzad, Hajjari, Mohammadreza, Mohammad Soltani, Bahram, Behmanesh, Mehrdad
Format: Article
Language:English
Subjects:
Adenocarcinoma
Antigens
Biomarkers
Breast
Cancer
Cell cycle
Forkhead protein
FOXC2
FOXQ1
Gastric Cancer
Gene Expression
Genes
Medical prognosis
Mesenchyme
Metastases
Metastasis
Original
Ovarian cancer
Polymerase chain reaction
Proteins
Quantitative Polymerase Chain Reaction
Real time
Regulators
Reverse transcription
Software
Statistical analysis
Studies
Tissues
Transcription factors
Tumors
Up-regulation
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Summary:Forkhead box (FOX) proteins are important regulators of the epithelial-to-mesenchymal transition (EMT), which is the main mechanism of cancer metastasis. Different studies have shown their potential involvement in progression of cancer in different tissues such as breast, ovary and colorectum. In this study, we aimed to analyze the expression of genes encoding two FOX proteins in gastric adenocarcinoma. In this experimental case-control study, the expression of and was examined in 31 gastric adenocarcinoma tumors and 31 normal adjacent gastric tissues by reverse transcription polymerase chain reaction (PCR). The expression of both genes was significantly up-regulated in gastric adenocarcinoma tumors compared with the normal tissues (P
ISSN:2228-5806
2228-5814
DOI:10.22074/cellj.2017.4357