Chitosan-Based Nanoparticles as Effective Drug Delivery Systems-A review

Chitosan-based nanoparticles (chitosan-based nanocomposites; chitosan nanoparticles; ChNPs) are promising materials that are receiving a lot of attention in the last decades. ChNPs have great potential as nanocarriers. They are able to encapsulate drugs as well as active compounds and deliver them t...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2023-02, Vol.28 (4), p.1963
Main Authors: Jafernik, Karolina, Ładniak, Agata, Blicharska, Eliza, Czarnek, Katarzyna, Ekiert, Halina, Wiącek, Agnieszka E, Szopa, Agnieszka
Format: Article
Language:English
Subjects:
Biocompatibility
Biopolymers
Chitin
Chitosan
Controlled release
Dosage and administration
Drug delivery
drug delivery efficacy
Drug delivery systems
Drugs
Molecular weight
nano-drugs
Nanocomposites
Nanoparticles
Oral administration
Particle size
Pharmaceutical industry
Polymers
Review
System effectiveness
Transdermal medication
Vehicles
Wound healing
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Summary:Chitosan-based nanoparticles (chitosan-based nanocomposites; chitosan nanoparticles; ChNPs) are promising materials that are receiving a lot of attention in the last decades. ChNPs have great potential as nanocarriers. They are able to encapsulate drugs as well as active compounds and deliver them to a specific place in the body providing a controlled release. In the article, an overview has been made of the most frequently used preparation methods, and the developed applications in medicine. The presentation of the most important information concerning ChNPs, especially chitosan's properties in drug delivery systems (DDS), as well as the method of NPs production was quoted. Additionally, the specification and classification of the NPs' morphological features determined their application together with the methods of attaching drugs to NPs. The latest scientific reports of the DDS using ChNPs administered orally, through the eye, on the skin and transdermally were taken into account.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28041963