Monoterpenoid Glycosides from the Leaves of Ligustrum robustum and Their Bioactivities

The leaves of Ligustrum robustum have been applied as Ku-Ding-Cha, a functional tea to clear heat, remove toxins, and treat obesity and diabetes, in Southwest China. The phytochemical research on the leaves of L. robustum led to the isolation and identification of eight new monoterpenoid glycosides...

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Published in:Molecules (Basel, Switzerland) Switzerland), 2022-06, Vol.27 (12), p.3709
Main Authors: Lu, Shi-Hui, Huang, Jing, Zuo, Hao-Jiang, Zhou, Zhong-Bo, Yang, Cai-Yan, Huang, Zu-Liang
Format: Article
Language:English
Subjects:
anti-obesity
antioxidant
Antioxidants
Ascorbic acid
Chemical industry
Diabetes mellitus
Ethanol
FAS
Fatty-acid synthase
Glucosidase
Glycosides
Hypoglycemia
Ligustrum
Ligustrum robustum
monoterpenoid glycoside
Obesity
Scavenging
Spectrum analysis
Tea
Toxins
α-Amylase
α-Glucosidase
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Summary:The leaves of Ligustrum robustum have been applied as Ku-Ding-Cha, a functional tea to clear heat, remove toxins, and treat obesity and diabetes, in Southwest China. The phytochemical research on the leaves of L. robustum led to the isolation and identification of eight new monoterpenoid glycosides (1–8) and three known monoterpenoid glycosides (9–11). Compounds 1–11 were tested for the inhibitory activities on fatty acid synthase (FAS), α-glucosidase, α-amylase, and the antioxidant effects. Compound 2 showed stronger FAS inhibitory activity (IC50: 2.36 ± 0.10 μM) than the positive control orlistat (IC50: 4.46 ± 0.13 μM), while compounds 1, 2, 5 and 11 displayed more potent ABTS radical scavenging activity (IC50: 6.91 ± 0.10~9.41 ± 0.22 μM) than the positive control L-(+)-ascorbic acid (IC50: 10.06 ± 0.19 μM). This study provided a theoretical basis for the leaves of L. robustum as a functional tea to treat obesity.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27123709