IFN-γ enhances the antitumor activity of attenuated salmonella-mediated cancer immunotherapy by increasing M1 macrophage and CD4 and CD8 T cell counts and decreasing neutrophil counts

Bacteria-mediated cancer immunotherapy (BCI) inhibits tumor progression and has a synergistic antitumor effect when combined with chemotherapy. The anti- or pro-tumorigenic effects of interferon-γ (IFN-γ) are controversial; hence, we were interested in the antitumor effects of IFN-γ/BCI combination...

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Bibliographic Details
Published in:Frontiers in bioengineering and biotechnology 2022-09, Vol.10, p.996055-996055
Main Authors: Xu, Huimin, Piao, Linghua, Wu, Yundi, Liu, Xiande
Format: Article
Language:English
Subjects:
BCI
Bioengineering and Biotechnology
IFN-γ
macrophage
neutrophil
S.tΔppGpp
T cell
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Summary:Bacteria-mediated cancer immunotherapy (BCI) inhibits tumor progression and has a synergistic antitumor effect when combined with chemotherapy. The anti- or pro-tumorigenic effects of interferon-γ (IFN-γ) are controversial; hence, we were interested in the antitumor effects of IFN-γ/BCI combination therapy. Here, we demonstrated that IFN-γ increased the tumor cell killing efficacy of attenuated Salmonella by prolonging the survival of tumor-colonizing bacteria via blockade of tumor-infiltrating neutrophil recruitment. In addition, IFN-γ attenuated Salmonella -stimulated immune responses by stimulating tumor infiltration by M1-like macrophages and CD4 + and CD8 + T cells, thereby facilitating tumor eradication. Taken together, these findings suggest that combination treatment with IFN-γ boosts the therapeutic response of BCI with S. tΔppGpp, suggesting that IFN-γ/BCI is a promising approach to immunotherapy.
ISSN:2296-4185
2296-4185
DOI:10.3389/fbioe.2022.996055