Enteric viral pathogens and child growth among under-five children: findings from South Asia and sub-Saharan Africa

Enteric viral pathogens are associated with a significant burden of childhood morbidity and mortality. We investigated the relationship between viral pathogens and child growth among under-5 children. We analyzed data from 5572/22,567 children enrolled in the Global Enteric Multicenter Study across...

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Bibliographic Details
Published in:Scientific reports 2024-06, Vol.14 (1), p.13871-12
Main Authors: Das, Rina, Haque, Md. Ahshanul, Kotloff, Karen L., Nasrin, Dilruba, Hossain, M. Jahangir, Sur, Dipika, Ahmed, Tahmeed, Levine, Myron M., Breiman, Robert F., Faruque, A. S. G., Freeman, Matthew C.
Format: Article
Language:English
Subjects:
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Africa South of the Sahara - epidemiology
Asia, Southern - epidemiology
Asymptomatic
Caliciviridae Infections - epidemiology
Child Development
Child, Preschool
Children
Children & youth
Diarrhea
Diarrhea - epidemiology
Diarrhea - virology
Female
Humanities and Social Sciences
Humans
Infant
Infant, Newborn
Male
Morbidity
multidisciplinary
Norovirus
Pathogens
Rotavirus
Rotavirus Infections - epidemiology
Science
Science (multidisciplinary)
Statistical analysis
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Summary:Enteric viral pathogens are associated with a significant burden of childhood morbidity and mortality. We investigated the relationship between viral pathogens and child growth among under-5 children. We analyzed data from 5572/22,567 children enrolled in the Global Enteric Multicenter Study across seven study sites (2007–2011). Multiple linear regression was used to examine the association between the viral pathogens and changes of length/height-for-age (HAZ), weight-for-age (WAZ), and weight-for-length/height (WHZ) z-scores, stratified by diarrheal symptoms and adjusted for potential covariates. Rotavirus (18.51%) and norovirus (7.33%) were the most prevalent enteric viral pathogens among symptomatic and asymptomatic under-5 children, respectively. Infection with individual enteric viral pathogens hurts child growth in asymptomatic children. However, the relationship with HAZ was less clear and statistically non-significant. On the other hand, the combined viral pathogens demonstrated a strong negative influence on child growth [WAZ: β coef.: − 0.10 (95%, CI − 0.15, − 0.05); P  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-64374-0