Artesunate-induced hemolysis in severe complicated malaria – A diagnostic challenge: A case report and literature review of anemia in malaria

Malaria infection, which results due to the parasitic protozoan Plasmodium, has several known etiologies of hemolytic anemia as a possible complication in cases such as concurrent G6PD deficiency, severe parasitemia, or use of parenteral antimalarials. Although artemisinin-based antimalarial therapi...

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Bibliographic Details
Published in:IDCases 2021-01, Vol.25, p.e01234, Article e01234
Main Authors: Sardar, Sundus, Abdurabu, Mohammed, Abdelhadi, Ahmed, Habib, Mhd Baraa, Jamshaid, Muhammad Bilal, Hajjar, Adnan Humam, Abu Ageila, Munir, Abdalla, Tasnim, Kartha, Anand, Farooqui, Khalid
Format: Article
Language:English
Subjects:
Anemia
Case Report
Malaria
PADH
Plasmodium falciparum
Post-artemisinin delayed hemolysis
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Summary:Malaria infection, which results due to the parasitic protozoan Plasmodium, has several known etiologies of hemolytic anemia as a possible complication in cases such as concurrent G6PD deficiency, severe parasitemia, or use of parenteral antimalarials. Although artemisinin-based antimalarial therapies are generally well-tolerated, several cases of severe post-artemisinin delayed hemolysis (PADH) have been recently reported, which present a diagnostic challenge, and affect morbidity and mortality in patients with malarial infection. We highlight the case of a young lady with Plasmodium falciparum severe parasitemia who developed hemolytic anemia after parenteral artesunate therapy.
ISSN:2214-2509
2214-2509
DOI:10.1016/j.idcr.2021.e01234