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Increasing incidence of invasive Haemophilus influenzae disease in adults, Utah, USA

Since the introduction of the Haemophilus influenzae type b vaccine, the incidence of invasive H. influenzae type b disease among children has fallen dramatically, but the effect on invasive H. influenzae disease among adults may be more complex. In this population-based study we examined the epidem...

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Bibliographic Details
Published in:Emerging infectious diseases 2011-09, Vol.17 (9), p.1645-1650
Main Authors: Rubach, Matthew P, Bender, Jeffrey M, Mottice, Susan, Hanson, Kimberly, Weng, Hsin Y C, Korgenski, Kent, Daly, Judy A, Pavia, Andrew T
Format: Article
Language:English
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Summary:Since the introduction of the Haemophilus influenzae type b vaccine, the incidence of invasive H. influenzae type b disease among children has fallen dramatically, but the effect on invasive H. influenzae disease among adults may be more complex. In this population-based study we examined the epidemiology and outcomes of invasive disease caused by typeable and nontypeable H. influenzae among Utah adults during 1998-2008. The overall incidence increased over the study period from 0.14/100,000 person-years in 1998 to 1.61/100,000 person-years in 2008. The average incidence in persons >65 years old was 2.74/100,000 person-years, accounting for 51% of cases and 67% of deaths. The incidence was highest for nontypeable H. influenzae (0.23/100,000 person-years), followed by H. influenzae type f (0.14/100,000 person-years). The case-fatality rate was 22%. The incidence of invasive H. influenzae in Utah adults appears to be increasing. Invasive H. influenzae infection disproportionately affected the elderly and was associated with a high mortality rate.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid1709.101991