The Known, the Unknown and the Future of the Pathophysiology of Endometriosis

Endometriosis is one of the most common causes of chronic pelvic pain and infertility, affecting 10% of women of reproductive age. A delay of up to 9 years is estimated between the onset of symptoms and the diagnosis of endometriosis. Endometriosis is currently defined as the presence of endometrial...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2024-06, Vol.25 (11), p.5815
Main Authors: Ochoa Bernal, Maria Ariadna, Fazleabas, Asgerally T
Format: Article
Language:English
Subjects:
Animals
B cells
Cell cycle
cytokines
Cytokines - metabolism
Defecation
Denervation
Development and progression
Disease Models, Animal
Endometriosis
Endometriosis - genetics
Endometriosis - metabolism
Endometriosis - pathology
Endometriosis - physiopathology
Endometrium
Endometrium - metabolism
Endometrium - pathology
Epigenetics
Estrogens
Female
fibrosis
Gene expression
Gynecology
Hormones
Humans
Immune system
Infertility
Injuries
Laparoscopy
Ligaments
Lymphatic system
Menstruation
microRNA
MicroRNAs - genetics
MicroRNAs - metabolism
origins
Ovaries
Pain
Pathophysiology
Pericardium
Review
Stem cells
Transplants & implants
Trauma
Uterus
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Endometriosis is one of the most common causes of chronic pelvic pain and infertility, affecting 10% of women of reproductive age. A delay of up to 9 years is estimated between the onset of symptoms and the diagnosis of endometriosis. Endometriosis is currently defined as the presence of endometrial epithelial and stromal cells at ectopic sites; however, advances in research on endometriosis have some authors believing that endometriosis should be re-defined as "a fibrotic condition in which endometrial stroma and epithelium can be identified". There are several theories on the etiology of the disease, but the origin of endometriosis remains unclear. This review addresses the role of microRNAs (miRNAs), which are naturally occurring post-transcriptional regulatory molecules, in endometriotic lesion development, the inflammatory environment within the peritoneal cavity, including the role that cytokines play during the development of the disease, and how animal models have helped in our understanding of the pathology of this enigmatic disease.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25115815