Comparison of Patient-Reported Outcomes Measures and Quality-Adjusted Life Years Following One- and Two-Stage Septic Knee Exchange

• Published in: Antibiotics (Basel) 2022-11, Vol.11 (11), p.1602
• Main Authors: Budin, Maximilian, Abuljadail, Salahulddin, Traverso, Giacomo, Ekhtiari, Seper, Gehrke, Thorsten, Sommer, Rachel, Citak, Mustafa
• Format: Article
• Language: English
• Subjects: Age; Antibiotics; Body mass index; Care and treatment; Comorbidity; Comparative analysis; Comparative studies; Complications; Debridement; Evaluation; Gender; Infection; Infections; Joint diseases; Joint surgery; Joints (anatomy); Knee; Length of stay; Medical research; Medicine, Experimental; Mortality; Normal distribution; one-stage; Patient outcomes; patient-reported outcome measures; Patients; periprosthetic joint infection; Postoperative; Pre-existing conditions; Pulmonary embolisms; quality adjusted life years; Quality of life; Questionnaires; Revisions; Statistical analysis; Surveys; Thrombosis; total knee arthroplasty; Transplants & implants; two-stage; Virulence
• ISSN: 2079-6382; 2079-6382
• DOI: 10.3390/antibiotics11111602

(1) Background: Periprosthetic joint infection (PJI) can be managed with one- or two-stage revision surgery protocol. Despite several studies analyzing the eradication rates between both procedures, there are no comparative studies that analyze patient-reported outcome measures (PROMs) and quality-adjusted life years (QALYs) in both treatment strategies. (2) Methods: All patients who underwent a two-stage knee revision between January 2017 to December 2018, due to a periprosthetic joint infection were included in the study. From the time interval, we selected a comparative group with the one-stage septic procedure. All patients received the following questionnaires: Oxford Knee Score, EQ-5D-5L, SSQ-8, and the SF-36. Additionally, demographic patient data were collected. The quality-adjusted life years (QALY) were calculated using the EQ-5D-5L. (3) Results: A total of 35 patients with a mean age of 67.7 years (SD = 8.9) were included in the final evaluation. The mean follow-up period was 54.5 months (SD = 5.5). There was no statistically significant difference regarding the Charlson Comorbidity Index (CCI), postoperative complications, or all evaluated questionnaires. There was no statistically significant difference in QALYs between the one- and two-stage revision. (4) Conclusion: Our study results show that the one-stage revision for PJI achieves similar PROMs compared to two-stage revision.