Regulation of cardiovascular diseases by histone deacetylases and NADPH oxidases

Histone deacetylases (HDACs) play critical roles in cardiovascular diseases (CVDs). In addition, reactive oxygen species (ROS) produced by NADPH oxidases (NOXs) exert damaging effects due to oxidative stress on heart and blood vessels. Although NOX-dependent ROS production is implicated in pathogene...

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Bibliographic Details
Published in:Redox biology 2024-11, Vol.77, p.103379, Article 103379
Main Authors: Yan, Hui, Yin, Yidan, Zhou, Yichen, Li, Zhanghang, Li, Yuxing, Ren, Lingxuan, Wen, Jiazheng, Wang, Weirong
Format: Article
Language:English
Subjects:
Animals
Cardiovascular diseases
Cardiovascular Diseases - etiology
Cardiovascular Diseases - metabolism
Histone Deacetylase Inhibitors - pharmacology
Histone Deacetylase Inhibitors - therapeutic use
Histone deacetylases
Histone Deacetylases - metabolism
Humans
NADPH oxidases
NADPH Oxidases - metabolism
Oxidative Stress
Reactive oxygen species
Reactive Oxygen Species - metabolism
Review
Signal Transduction
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Summary:Histone deacetylases (HDACs) play critical roles in cardiovascular diseases (CVDs). In addition, reactive oxygen species (ROS) produced by NADPH oxidases (NOXs) exert damaging effects due to oxidative stress on heart and blood vessels. Although NOX-dependent ROS production is implicated in pathogenesis, the relationship between HDACs and NOXs in CVDs remains to be elucidated. Here, we present an overview of the regulatory effects and interconnected signaling pathways of HDACs and NOXs in CVDs. Improved insights into these relationships will facilitate the discovery of novel therapeutic agents that target HDACs, oxidase stress pathways, and the interactions between these systems which may be highly effective in the prevention and treatment of cardiovascular disorders.
ISSN:2213-2317
2213-2317
DOI:10.1016/j.redox.2024.103379