Exploring peptide studies related to SARS-CoV to accelerate the development of novel therapeutic and prophylactic solutions against COVID-19

Recent advances in peptide research revolutionized therapeutic discoveries for various infectious diseases. In view of the ongoing threat of the COVID-19 pandemic, there is an urgent need to develop potential therapeutic options. Intense and accomplishing research is being carried out to develop bro...

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Bibliographic Details
Published in:Journal of infection and public health 2021-08, Vol.14 (8), p.1106-1119
Main Authors: Madhavan, Maya, AlOmair, Lamya A., KS, Deepthi, Mustafa, Sabeena
Format: Article
Language:English
Subjects:
Antiviral Agents - therapeutic use
COVID-19 Drug Treatment
Humans
Immune system
Pandemics
Peptide therapeutics
Peptides
Review
SARS-CoV-2
Spike protein
Viral entry
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Summary:Recent advances in peptide research revolutionized therapeutic discoveries for various infectious diseases. In view of the ongoing threat of the COVID-19 pandemic, there is an urgent need to develop potential therapeutic options. Intense and accomplishing research is being carried out to develop broad-spectrum vaccines and treatment options for corona viruses, due to the risk of recurrent infection by the existing strains or pandemic outbreaks by new mutant strains. Developing a novel medicine is costly and time consuming, which increases the value of repurposing existing therapies. Since, SARS-CoV-2 shares significant genomic homology with SARS-CoV, we have summarized various peptides identified against SARS-CoV using in silico and molecular studies and also the peptides effective against SARS-CoV-2. Dissecting the molecular mechanisms underlying viral infection could yield fundamental insights in the discovery of new antiviral agents, targeting viral proteins or host factors. We postulate that these peptides can serve as effective components for therapeutic options against SARS-CoV-2, supporting clinical scientists globally in selectively identifying and testing the therapeutic and prophylactic agents for COVID-19 treatment. In addition, we also summarized the latest updates on peptide therapeutics against SARS-CoV-2.
ISSN:1876-0341
1876-035X
1876-035X
DOI:10.1016/j.jiph.2021.06.017