A dose-response curve for biodosimetry from a 6 MV electron linear accelerator

Biological dosimetry (biodosimetry) is based on the investigation of radiation-induced biological effects (biomarkers), mainly dicentric chromosomes, in order to correlate them with radiation dose. To interpret the dicentric score in terms of absorbed dose, a calibration curve is needed. Each curve...

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Bibliographic Details
Published in:Brazilian journal of medical and biological research 2015-10, Vol.48 (10), p.908-914
Main Authors: Lemos-Pinto, M M P, Cadena, M, Santos, N, Fernandes, T S, Borges, E, Amaral, A
Format: Article
Language:English
Subjects:
Adult
CABAS
Calibration - standards
Calibration curves
Chromosome Aberrations - radiation effects
Dicentrics
Dose Estimate
Dose-Response Relationship, Radiation
Electrons
Humans
Leukocytes, Mononuclear - radiation effects
Linear accelerator
Male
Particle Accelerators
Primary Cell Culture
Radiation Dosage
Radiometry - methods
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Summary:Biological dosimetry (biodosimetry) is based on the investigation of radiation-induced biological effects (biomarkers), mainly dicentric chromosomes, in order to correlate them with radiation dose. To interpret the dicentric score in terms of absorbed dose, a calibration curve is needed. Each curve should be constructed with respect to basic physical parameters, such as the type of ionizing radiation characterized by low or high linear energy transfer (LET) and dose rate. This study was designed to obtain dose calibration curves by scoring of dicentric chromosomes in peripheral blood lymphocytes irradiated in vitro with a 6 MV electron linear accelerator (Mevatron M, Siemens, USA). Two software programs, CABAS (Chromosomal Aberration Calculation Software) and Dose Estimate, were used to generate the curve. The two software programs are discussed; the results obtained were compared with each other and with other published low LET radiation curves. Both software programs resulted in identical linear and quadratic terms for the curve presented here, which was in good agreement with published curves for similar radiation quality and dose rates.
ISSN:0100-879X
1414-431X
DOI:10.1590/1414-431X20154470