LOX upregulates FAK phosphorylation to promote metastasis in osteosarcoma

Osteosarcoma is a malignant bone tumor that commonly occurs in the pediatric population. Despite the use of chemotherapy and surgery, metastasis remains to be the leading cause of death in patients with osteosarcoma. We have previously reported that cytoplasmic mislocalization of p27 is associated w...

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Bibliographic Details
Published in:Genes & diseases 2023-01, Vol.10 (1), p.254-266
Main Authors: Chen, Xiang, Clement, Margaret, Hicks, M. John, Sarkar, Poonam, Gaber, M. Waleed, Man, Tsz-Kwong
Format: Article
Language:English
Subjects:
Focal adhesion kinase
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Lysyl oxidase
Metastasis
Osteosarcoma
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Summary:Osteosarcoma is a malignant bone tumor that commonly occurs in the pediatric population. Despite the use of chemotherapy and surgery, metastasis remains to be the leading cause of death in patients with osteosarcoma. We have previously reported that cytoplasmic mislocalization of p27 is associated with a poor outcome in osteosarcoma. In this study, we further show that lysyl oxidase (LOX) expression was associated with p27 mislocalization. LOX is an enigmatic molecule that acts as a tumor suppressor or a metastatic promoter; however, its role in osteosarcoma is still unclear. Hence, we performed both in vitro and in vivo analyses to dissect the role of LOX in osteosarcoma. The result of our survival analysis indicated that LOX expression significantly correlated with a poor outcome in osteosarcoma with or without controlling for the initial metastasis status (P 
ISSN:2352-3042
2352-4820
2352-3042
DOI:10.1016/j.gendis.2021.12.016