Synthesis and characterization of some new Cu(II), Ni(II) and Zn(II) complexes with salicylidene thiosemicarbazones: antibacterial, antifungal and in vitro antileukemia activity

Thirty two new Cu(II), Ni(II) and Zn(II) complexes (1-32) with salicylidene thiosemicarbazones (H₂L¹-H₂L¹⁰) were synthesized. Salicylidene thiosemicarbazones, of general formula (X)N-NH-C(S)-NH(Y), were prepared through the condensation reaction of 2-hydroxybenzaldehyde and its derivatives (X) with...

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Published in:Molecules (Basel, Switzerland) Switzerland), 2013-07, Vol.18 (8), p.8812-8836
Main Authors: Pahontu, Elena, Fala, Valeriu, Gulea, Aurelian, Poirier, Donald, Tapcov, Victor, Rosu, Tudor
Format: Article
Language:English
Subjects:
Aldehydes - chemical synthesis
Aldehydes - chemistry
Aldehydes - pharmacology
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - pharmacology
antileukemia
antimicrobial activity
Cell growth
Coordination Complexes - chemical synthesis
Coordination Complexes - chemistry
Coordination Complexes - pharmacology
Copper
Copper - chemistry
Copper - pharmacology
Crystallography, X-Ray
Electrolytes
Ethanol
Humans
Inorganic chemistry
Leukemia
Ligands
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Molecular Structure
nickel
Nickel - chemistry
Nickel - pharmacology
Pharmacy
Salmonella
thiosemicarbazones
Thiosemicarbazones - chemical synthesis
Thiosemicarbazones - chemistry
Thiosemicarbazones - pharmacology
Zinc - chemistry
Zinc - pharmacology
zinc complexes
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Summary:Thirty two new Cu(II), Ni(II) and Zn(II) complexes (1-32) with salicylidene thiosemicarbazones (H₂L¹-H₂L¹⁰) were synthesized. Salicylidene thiosemicarbazones, of general formula (X)N-NH-C(S)-NH(Y), were prepared through the condensation reaction of 2-hydroxybenzaldehyde and its derivatives (X) with thiosemicarbazide or 4-phenylthiosemicarbazide (Y = H, C6H5). The characterization of the new formed compounds was done by ¹H-NMR, ¹³C-NMR, IR spectroscopy, elemental analysis, magnetochemical, thermoanalytical and molar conductance measurements. In addition, the structure of the complex 5 has been determined by X-ray diffraction method. All ligands and metal complexes were tested as inhibitors of human leukemia (HL-60) cells growth and antibacterial and antifungal activities.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules18088812