Softness enhanced macrophage-mediated therapy of inhaled apoptotic-cell-inspired nanosystems for acute lung injury

• Published in: Journal of nanobiotechnology 2023-05, Vol.21 (1), p.172-172, Article 172
• Main Authors: Sun, Dazheng, Zhang, Guanglin, Xie, Mingyang, Wang, Yina, Liang, Xiangchao, Tu, Mei, Su, Zhijian, Zeng, Rong
• Format: Article
• Language: English
• Subjects: Acetylcysteine; Acetylcysteine - metabolism; Acetylcysteine - pharmacology; Acetylcysteine - therapeutic use; Acute lung injury; Acute Lung Injury - chemically induced; Acute Lung Injury - drug therapy; Acute respiratory distress syndrome; Animals; Anti-inflammatory; Apoptosis; Apoptotic-cell-inspired; Bleomycin; Bone marrow; Care and treatment; Cellular therapy; Coronaviruses; COVID-19; Disease transmission; Drug delivery systems; Effectiveness; Epithelial cells; Epithelium; Health aspects; Inflammation; Inflammatory diseases; Inflammatory response; Injuries; Laboratory animals; Ligands; Lipids; Lung - metabolism; Lungs; Macrophage; Macrophages; Macrophages - metabolism; Mechanical properties; Mice; Microscopy; Modulus of elasticity; Mortality; Nanomedicine; Nanoparticles; Phosphatidylserine; Sodium; Softness; Synergistic effect; Therapeutics, Experimental; Tumor necrosis factor-TNF; Wound healing
• ISSN: 1477-3155; 1477-3155
• DOI: 10.1186/s12951-023-01930-2

Engineered nanosystems offer a promising strategy for macrophage-targeted therapies for various diseases, and their physicochemical parameters including surface-active ligands, size and shape are widely investigated for improving their therapeutic efficacy. However, little is known about the synergistic effect of elasticity and surface-active ligands. Here, two kinds of anti-inflammatory N-acetylcysteine (NAC)-loaded macrophage-targeting apoptotic-cell-inspired phosphatidylserine (PS)-containing nano-liposomes (PSLipos) were constructed, which had similar size and morphology but different Young's modulus (E) (H, ~ 100 kPa > E vs. L, ~ 2 kPa