BNP and NT-proBNP as Diagnostic Biomarkers for Cardiac Dysfunction in Both Clinical and Forensic Medicine

Currently, brain natriuretic peptide (BNP) and -terminal proBNP (NT-proBNP) are widely used as diagnostic biomarkers for heart failure (HF) and cardiac dysfunction in clinical medicine. They are also used as postmortem biomarkers reflecting cardiac function of the deceased before death in forensic m...

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Bibliographic Details
Published in:International journal of molecular sciences 2019-04, Vol.20 (8), p.1820
Main Authors: Cao, Zhipeng, Jia, Yuqing, Zhu, Baoli
Format: Article
Language:English
Subjects:
Amino acids
Angiotensin
Angiotensin II
Autocrine signalling
Biomarkers
BNP
Brain natriuretic peptide
Brain research
cardiac dysfunction
Cardiac function
Cardiomyocytes
Congestive heart failure
Diagnostic systems
Enzymes
Extracellular matrix
Extracellular signal-regulated kinase
Forensic medicine
Forensic pathology
Forensic science
Gene expression
Heart attacks
Heart failure
Kinases
MAP kinase
Mortality
Neprilysin
NT-proBNP
Paracrine signalling
Peptides
Physiology
postmortem biochemistry
Protein kinase
Proteins
Regulatory agencies
Review
Signal transduction
Thyroid gland
Transcription factors
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Summary:Currently, brain natriuretic peptide (BNP) and -terminal proBNP (NT-proBNP) are widely used as diagnostic biomarkers for heart failure (HF) and cardiac dysfunction in clinical medicine. They are also used as postmortem biomarkers reflecting cardiac function of the deceased before death in forensic medicine. Several previous studies have reviewed BNP and NT-proBNP in clinical medicine, however, few articles have reviewed their application in forensic medicine. The present article reviews the biological features, the research and application status, and the future research prospects of BNP and NT-proBNP in both clinical medicine and forensic medicine, thereby providing valuable assistance for clinicians and forensic pathologists.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms20081820