Extra-Skeletal Effects of Vitamin D

The vitamin D receptor is expressed in multiple cells of the body (other than osteoblasts), including beta cells and cells involved in immune modulation (such as mononuclear cells, and activated T and B lymphocytes), and most organs in the body including the brain, heart, skin, gonads, prostate, bre...

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Bibliographic Details
Published in:Nutrients 2019-06, Vol.11 (7), p.1460
Main Authors: Marino, Rose, Misra, Madhusmita
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
autoimmune
Autoimmunity
Biomarkers - blood
cancer
Child
Child, Preschool
children
Dietary Supplements
Female
Humans
Male
Meta-Analysis as Topic
metabolic syndrome
Middle Aged
Noncommunicable Diseases - epidemiology
Noncommunicable Diseases - prevention & control
Prognosis
Randomized Controlled Trials as Topic
Receptors, Calcitriol - metabolism
Review
Risk Assessment
Risk Factors
Signal Transduction
type 1 diabetes
type 2 diabetes
Ultraviolet radiation
Vitamin D
Vitamin D - blood
Vitamin D - therapeutic use
Vitamin D Deficiency - blood
Vitamin D Deficiency - diagnosis
Vitamin D Deficiency - drug therapy
Vitamin D Deficiency - epidemiology
Young Adult
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Description
Summary:The vitamin D receptor is expressed in multiple cells of the body (other than osteoblasts), including beta cells and cells involved in immune modulation (such as mononuclear cells, and activated T and B lymphocytes), and most organs in the body including the brain, heart, skin, gonads, prostate, breast, and gut. Consequently, the extra-skeletal impact of vitamin D deficiency has been an active area of research. While epidemiological and case-control studies have often suggested a link between vitamin D deficiency and conditions such as type 1 and type 2 diabetes, connective tissue disorders, inflammatory bowel disorders, chronic hepatitis, food allergies, asthma and respiratory infections, and cancer, interventional studies for the most part have failed to confirm a causative link. This review examines available evidence to date for the extra-skeletal effects of vitamin D deficiency, with a focus on randomized controlled trials and meta-analyses.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu11071460