Computational methods for biofabrication in tissue engineering and regenerative medicine - a literature review

• Published in: Computational and structural biotechnology journal 2024-12, Vol.23, p.601-616
• Main Authors: Bardini, Roberta, Di Carlo, Stefano
• Format: Article
• Language: English
• Subjects: Biofabrication; Computational biology; Optimization via simulation; Regenerative medicine; Tissue engineering
• ISSN: 2001-0370; 2001-0370
• DOI: 10.1016/j.csbj.2023.12.035

This literature review rigorously examines the growing scientific interest in computational methods for Tissue Engineering and Regenerative Medicine biofabrication, a leading-edge area in biomedical innovation, emphasizing the need for accurate, multi-stage, and multi-component biofabrication process models. The paper presents a comprehensive bibliometric and contextual analysis, followed by a literature review, to shed light on the vast potential of computational methods in this domain. It reveals that most existing methods focus on single biofabrication process stages and components, and there is a significant gap in approaches that utilize accurate models encompassing both biological and technological aspects. This analysis underscores the indispensable role of these methods in understanding and effectively manipulating complex biological systems and the necessity for developing computational methods that span multiple stages and components. The review concludes that such comprehensive computational methods are essential for developing innovative and efficient Tissue Engineering and Regenerative Medicine biofabrication solutions, driving forward advancements in this dynamic and evolving field.