Influence of rs6667202 SNP on Interleukin-10 levels in the gingival fluid of patients with periodontitis grade C

Grade C periodontitis in youngers is characterized by a severe form of periodontitis, and IL10 rs6667202 single nucleotide polymorphism (SNP) has been described as an important feature in this disease etiology. Aim: This study aimed to evaluate, in vivo, the functionality of IL10 rs6667202 SNP on IL...

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Bibliographic Details
Published in:Brazilian journal of oral sciences 2021-02, Vol.20, p.e211654-e211654
Main Authors: Stolf, Camila Schmidt, Taiete, Tiago, Zaffalon Casati, Márcio, Sallum, Enílson Antônio, Nociti Júnior, Francisco Humberto, Ruiz, Karina Gonzales Silvério, Casarin, RenatoCorrêa Viana
Format: Article
Language:English
Subjects:
aggressive periodontitis
interleukin-10
polymorphism, single nucleotide
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Summary:Grade C periodontitis in youngers is characterized by a severe form of periodontitis, and IL10 rs6667202 single nucleotide polymorphism (SNP) has been described as an important feature in this disease etiology. Aim: This study aimed to evaluate, in vivo, the functionality of IL10 rs6667202 SNP on IL-10 gingival fluid levels. Methods: Thirty patients with Perio4C were selected, 15 with the IL10 AA genotype (rs6667202) and 15 with AC/CC genotypes. The gingival fluid was collected from two sites with probing depth ≥ 7 mm and bleeding on probing, and two healthy sites. The IL-10 concentration was determined by Luminex/MAGpix platform. Results: In deep pockets, the IL10 AA genotype presented a lower concentration of IL-10 when compared with AC or CC genotypes (p0.05). Conclusion: IL10 rs6667202 SNP decreases the production of IL-10 in crevicular fluid, potentially affecting this disease progression.  
ISSN:1677-3225
1677-3225
DOI:10.20396/bjos.v20i00.8661654