Evaluation of the Antioxidative, Antibacterial, and Anti-Inflammatory Effects of the Aloe Fermentation Supernatant Containing Lactobacillus plantarum HM218749.1

• Published in: Mediators of Inflammation 2016-01, Vol.2016 (2016), p.786-793-071
• Main Authors: Deng, Keyu, Chen, Tingtao, Xin, Hongbo, Meng, Fanjing, Wang, Xin, Wang, Xiaolei, Guo, Chunlan, Fu, Mingui, Jiang, Chunling, Deng, Kan, Jiang, Meixiu, Yang, Shaoguo
• Format: Article
• Language: English
• Subjects: Aloe - chemistry; Analysis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - pharmacology; Anti-inflammatory drugs; Antibacterial agents; Antimicrobial agents; Antioxidants; Antioxidants - chemistry; Chronic diseases; Escherichia coli; Escherichia coli - drug effects; Fermentation; Functional foods & nutraceuticals; Interleukin-1beta - genetics; Interleukin-1beta - metabolism; Interleukin-6 - genetics; Interleukin-6 - metabolism; Lactobacillus plantarum - metabolism; Listeria monocytogenes - drug effects; Microorganisms; Probiotics; Propionibacterium acnes - drug effects; Proteins; Salmonella enteritidis - drug effects; Salmonella typhimurium - drug effects; Shigella flexneri - drug effects; Staphylococcus aureus - drug effects; Tumor Necrosis Factor-alpha - genetics; Tumor Necrosis Factor-alpha - metabolism
• ISSN: 0962-9351; 1466-1861
• DOI: 10.1155/2016/2945650

Little work is done to develop Aloe vera (AV) using probiotics. To explore the potential benefits, the antioxidant effects and the antibacterial effects on foodborne pathogens of Aloe fermentation supernatant were evaluated in vitro. Our results indicated that the Aloe fermentation supernatant fermented by Lactobacillus plantarum HM218749.1 had very strong scavenging capacities of the DPPH (86%), O 2 • - (85%), O H • (76%), and F e 2 + chelation (82%) and reducing powers (242.5 mg/L), and the inhibition zones for Salmonella typhimurium, Salmonella enteritidis, Shigella flexneri, Escherichia coli, Listeria monocytogenes, S. dysenteriae 301, Staphylococcus aureus Cowan1, and Propionibacterium acnes were 16, 15, 19, 20, 21, 20, and 27 mm. Moreover, the low concentration of Aloe fermentation supernatant had significantly reduced the production of IL-1β, TNF-α, and IL-6 in both mRNA and protein levels ( P < 0.01 ). Therefore, the Aloe fermentation supernatant can be used as functional beverage or cosmetic ingredients to guard human intestinal health, delaying senescence, and prevent chronic diseases.