Uptake and continuation of HIV pre‐exposure prophylaxis among women of reproductive age in two health facilities in Kisumu County, Kenya

• Published in: Journal of the International AIDS Society 2023-03, Vol.26 (3), p.e26069-n/a
• Main Authors: Ogolla, Mercelline, Nyabiage, Omoto Lennah, Musingila, Paul, Gachau, Susan, Odero, Theresa M. A., Odoyo‐June, Elijah, Ochanda, Boniface, Appolonia, Aoko, Katiku, Elizabeth, Joseph, Rachael, Ogolla, Cirrilus, Otieno, Linda, Odhiambo, Francesca, Truong, Hong‐Ha M.
• Format: Article
• Language: English
• Subjects: Acquired immune deficiency syndrome; Adolescent; adolescent girls and young women; Adult; AIDS; Anti-HIV Agents - therapeutic use; Central business districts; Clinical trials; Condoms; continuation; Disease prevention; Family planning; Female; Health Facilities; HIV; HIV Infections - drug therapy; HIV prevention; Human immunodeficiency virus; Humans; Infections; Kenya - epidemiology; Maternal & child health; Medical tests; Middle Aged; Missing data; oral pre‐exposure prophylaxis; Pre-Exposure Prophylaxis; Prophylaxis; Regression analysis; Retrospective Studies; Risk assessment; Sexually transmitted diseases; Sociodemographics; STD; uptake; Urban areas; women of reproductive age; Womens health; Young Adult
• ISSN: 1758-2652; 1758-2652
• DOI: 10.1002/jia2.26069

Introduction In 2020, Kenya had 19,000 new HIV infections among women aged 15+ years. Studies have shown sub‐optimal oral pre‐exposure prophylaxis (PrEP) use among sub‐populations of women. We assessed the uptake and continuation of oral PrEP among women 15–49 years in two health facilities in Kisumu County, Kenya. Methods A retrospective cohort of 262 women aged 15–49 years, initiated into oral PrEP between 12 November 2019 and 31 March 2021, was identified from two health facilities in the urban setting of Kisumu County, Kenya. Data on baseline characteristics and oral PrEP continuation at months 1, 3 and 6 were ed from patient records and summarized using descriptive statistics. Missing data in the predictor variables were imputed within the joint modelling multiple imputation framework. Using logistic regression, we evaluated factors associated with the discontinuation of oral PrEP at month 1. Results Of the 66,054 women screened, 320 (0.5%) were eligible and 262 (82%) were initiated on oral PrEP. Uptake was higher among women 25–29 years as compared to those 15–24 years (77% vs. 33%). Oral PrEP continuation declined significantly with increasing duration of follow‐up; 37% at month 1, 21% at month 3 and 12% at month 6 (p