Oxidant-Antioxidant Balance during On-Pump Coronary Artery Bypass Grafting

• Published in: TheScientificWorld 2014-01, Vol.2014 (2014), p.1-5
• Main Authors: Alver, Ahmet, Aykan, Ahmet Cagri, Demir, Selim, Oztas Mentese, Seda, Dogan, Emre, Usta, Sefer, Turan, Ibrahim, Dogan, Orhan Veli, Mentese, Umit, Özer, Tanıl
• Format: Article
• Language: English
• Subjects: Acute coronary syndromes; Aged; Analysis; Antioxidants; Antioxidants - metabolism; Chromans - blood; Clinical Study; Coronary artery bypass; Coronary Artery Bypass - methods; Coronary Artery Disease - blood; Coronary Artery Disease - pathology; Coronary Artery Disease - surgery; Coronary vessels; Coronary Vessels - metabolism; Coronary Vessels - pathology; Coronary Vessels - surgery; Emergency medical care; Female; Heart surgery; Humans; Hydrogen Peroxide - blood; Infusion Pumps; Male; Middle Aged; Oxidants - blood; Oxidation-Reduction; Oxidative Stress; Oxidizing agents; Statistical analysis; Studies; Veins & arteries
• ISSN: 2356-6140; 1537-744X; 1537-744X
• DOI: 10.1155/2014/263058

Backround. The aim of this study was to evaluate the changes in perioperative oxidant-antioxidant balance in ONCABG. Methods. Twenty-three patients were included in this study. Serum total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) values were assessed preoperatively, at 20 minutes after aortic clamping and at 30 minutes, 6 hours, and 48 hours after declamping (reperfusion). The patients were divided into 2 groups according to the median aortic cross clamping (XC) time: group 1 (XC time < 42 minutes) and group 2 (XC time ≥ 42 minutes). Results. TOS and OSI values of whole patients at 30 minutes after reperfusion were higher than preoperative values ( P = 0.045 , P = 0.015 ), while perioperative TAS levels of the patients were similar to the preoperative levels ( P = 0.173 ). XC time was correlated with TOS levels at 30 minutes after reperfusion ( r = 0.43 , P = 0.041 ). In group 2, TOS and OSI values at 30 minutes after reperfusion were higher than preoperative values ( P = 0.023 , P = 0.048 ), whereas a significant difference was not found in group 1 ( P = 0.601 , P = 0.327 ). Conclusions. Oxidative imbalance and increase in TOS at reperfusion in ONCABG may be associated with XC time.