Effects of pressure-controlled ventilation targeting end-inspiratory flow rate on pulmonary complications and inflammation levels in patients undergoing spinal surgery in the prone position: a randomized clinical trial

• Published in: BMC anesthesiology 2024-02, Vol.24 (1), p.59-9, Article 59
• Main Authors: Wang, Na, Ye, Yong, Lin, Hui, Sun, Tingting, Hu, Yue, Shu, Yuanhang, Tong, Jing, Tao, Yong, Zhao, Zeyu
• Format: Article
• Language: English
• Subjects: Airports; Back surgery; C-reactive protein; Clinical trials; Complications and side effects; End-inspiratory flow rate; General anesthesia; Humans; Inflammation; Interleukin 6; Interleukins; Intubation; Orthopedic surgery; Patients; Pressure-controlled ventilation; Prone Position; Respiration; Respiration, Artificial; Respiratory Distress Syndrome; Spinal surgery; Surgery; Tidal Volume; Variance analysis; Ventilation
• ISSN: 1471-2253; 1471-2253
• DOI: 10.1186/s12871-024-02439-3

This study assessed the impact of pressure-controlled ventilation (PCV) focusing on end-inspiratory flow rate on the incidence of postoperative pulmonary complications (PPCs) and inflammation levels in patients undergoing spinal surgery in the prone position. A total of 187 patients who underwent posterior spinal surgery were enrolled and randomly divided into 3 groups: 61 in the volume-controlled ventilation (VCV) group (group V), 62 in the PCV-volume-guaranteed (VG) group (group P ), and 64 in the PCV-VG end-expiratory zero flow rate group (group P ). Indicators including tidal volume (V ), peak airway pressure (P ), and dynamic lung compliance (Cdyn) were recorded. The P , Cdyn, P CO2, and oxygenation index (PaO /FiO ) after intubation (T ), after prone position (T ), 60 min after prone position (T ), and after supine position at the end of surgery (T ) of the three groups were collected. In the within-group comparison, compared with T , P increased at T in groups V and P (P