Non-Cell-Autonomous Neurotoxicity in Parkinson’s Disease Mediated by Astroglial α-Synuclein

Non-cell-autonomous effects on neuronal cells are considered to be involved in the pathogenesis of neurodegenerative diseases but have yet to be mechanistically proven. In this issue of Stem Cell Reports, di Domenico et al. provide direct evidence that α-synuclein transferred from astrocytes exerts...

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Bibliographic Details
Published in:Stem cell reports 2019-02, Vol.12 (2), p.183-185
Main Authors: Chai, MuhChyi, Kohyama, Jun
Format: Article
Language:English
Subjects:
alpha-Synuclein - metabolism
Animals
Astrocytes - metabolism
Astrocytes - pathology
Dopaminergic Neurons - pathology
Humans
Parkinson Disease - metabolism
Parkinson Disease - pathology
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Stem Cells - metabolism
Stem Cells - pathology
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Summary:Non-cell-autonomous effects on neuronal cells are considered to be involved in the pathogenesis of neurodegenerative diseases but have yet to be mechanistically proven. In this issue of Stem Cell Reports, di Domenico et al. provide direct evidence that α-synuclein transferred from astrocytes exerts non-cell-autonomous neuronal dysfunction on dopaminergic neurons in Parkinson’s disease (PD). Non-cell-autonomous effects on neuronal cells are considered to be involved in the pathogenesis of neurodegenerative diseases but have yet to be mechanistically proven. In this issue of Stem Cell Reports, di Domenico et al. provide direct evidence that α-synuclein transferred from astrocytes exerts non-cell-autonomous neuronal dysfunction on dopaminergic neurons in Parkinson’s disease (PD).
ISSN:2213-6711
2213-6711
DOI:10.1016/j.stemcr.2019.01.011