Effect of Plasma Treatment of Titanium Surface on Biocompatibility

It was recently reported that implant osseointegration is affected by surface wettability. The relationship between hydrophilicity and cell adhesion was corroborated by numerous in vivo studies. Concentrated alkali improves the biocompatibility of pure titanium. Research was conducted on the mechani...

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Bibliographic Details
Published in:Applied sciences 2019-06, Vol.9 (11), p.2257
Main Authors: Ujino, Daiga, Nishizaki, Hiroshi, Higuchi, Shizuo, Komasa, Satoshi, Okazaki, Joji
Format: Article
Language:English
Subjects:
Adhesion
Adsorption
Alkaline phosphatase
Atmospheric pressure
Biocompatibility
Biomedical materials
Bone marrow
Bovine serum albumin
Cell adhesion
Cell adhesion & migration
Cell differentiation
Concentration cell corrosion
Contact angle
Differentiation
Gene expression
Health sciences
Hydrophilicity
In vivo methods and tests
Microscopy
Osseointegration
Photoelectron spectroscopy
Photoelectrons
piezobrush
Plasma
Plasma processing
Proteins
rat bone marrow cell
Scanning electron microscopy
Scanning probe microscopy
Serum albumin
Studies
superhydrophilicity
Surface properties
Surgical implants
Titanium
Transplants & implants
Wettability
X ray photoelectron spectroscopy
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Summary:It was recently reported that implant osseointegration is affected by surface wettability. The relationship between hydrophilicity and cell adhesion was corroborated by numerous in vivo studies. Concentrated alkali improves the biocompatibility of pure titanium. Research was conducted on the mechanism by which this treatment increases hydrophilicity. In the present study, we used atmospheric pressure plasma processing to enhance the hydrophilicity of the material surface. The aim was to assess its influences on the initial adhesion of the material to rat bone marrow and subsequent differentiation into hard tissue. Superhydrophilicity was induced on a pure titanium surface with a piezobrush, a simple, compact alternative to the conventional atmospheric pressure plasma device. No structural change was confirmed by Scanning electron microscope (SEM) or scanning probe microscopy (SPM) observation. X-ray photoelectron spectroscopy (XPS) analysis presented with hydroxide formation and a reduction in the C peak. A decrease in contact angle was also observed. The treated samples had higher values for in vitro bovine serum albumin (BSA) adsorption, rat bone marrow (RBM) cell initial adhesion, alkaline phosphatase activity (ALP) activity tests, and factors related to bone differentiation than the untreated control. The present study indicated that the induction of superhydrophilicity in titanium via atmospheric pressure plasma treatment with a piezobrush affects RBM cell adhesion and bone differentiation without altering surface properties.
ISSN:2076-3417
2076-3417
DOI:10.3390/app9112257