Roles of Ubiquitination and Deubiquitination in Regulating Dendritic Cell Maturation and Function

Dendritic cells (DCs) are specialized antigen-presenting cells that play a key role in immune homeostasis and the adaptive immune response. DC-induced immune tolerance or activation is strictly dependent on the distinct maturation stages and migration ability of DCs. Ubiquitination is a reversible p...

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Bibliographic Details
Published in:Frontiers in immunology 2020-11, Vol.11, p.586613-586613
Main Authors: Zhu, Bo, Zhu, Lihua, Xia, Lin, Xiong, Yuyun, Yin, Qing, Rui, Ke
Format: Article
Language:English
Subjects:
DC maturation
dendritic cells
immune responses
Immunology
post-translational modification
ubiquitination
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Summary:Dendritic cells (DCs) are specialized antigen-presenting cells that play a key role in immune homeostasis and the adaptive immune response. DC-induced immune tolerance or activation is strictly dependent on the distinct maturation stages and migration ability of DCs. Ubiquitination is a reversible protein post-translational modification process that has emerged as a crucial mechanism that regulates DC maturation and function. Recent studies have shown that ubiquitin enzymes, including E3 ubiquitin ligases and deubiquitinases (DUBs), are pivotal regulators of DC-mediated immune function and serve as potential targets for DC-based immunotherapy of immune-related disorders (e.g., autoimmune disease, infections, and tumors). In this review, we summarize the recent progress regarding the molecular mechanisms and function of ubiquitination in DC-mediated immune homeostasis and immune response.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2020.586613