CYP2C8 gene polymorphism and bisphosphonate-related osteonecrosis of the jaw in patients with multiple myeloma

• Published in: Haematologica (Roma) 2011-10, Vol.96 (10), p.1557-1559
• Main Authors: SUCH, Esperanza, CERVERA, José, ROIG, Mónica, SANZ, Miguel A, DIMOPOULOS, Meletios A, DE LA RUBIA, Javier, TERPOS, Evangelos, BAGAN, Jose V, AVARIA, Amparo, GOMEZ, Inés, MARGAIX, Maria, IBANEZ, Mariam, LUNA, Irene, CORDON, Lourdes
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Alleles; Aryl Hydrocarbon Hydroxylases - genetics; Biological and medical sciences; Bisphosphonate-Associated Osteonecrosis of the Jaw - complications; Bisphosphonate-Associated Osteonecrosis of the Jaw - genetics; Brief Reports; Cytochrome P-450 CYP2C8; Diseases of the osteoarticular system; Female; Genotype; Hematologic and hematopoietic diseases; Humans; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Male; Medical sciences; Middle Aged; Multiple Myeloma - complications; Multiple Myeloma - drug therapy; Multiple Myeloma - genetics; Polymorphism, Single Nucleotide; Vascular bone diseases
• ISSN: 0390-6078; 1592-8721
• DOI: 10.3324/haematol.2011.042572

Osteonecrosis of the jaw is an uncommon but potentially serious complication of bisphosphonate therapy in multiple myeloma. Previous studies showed that the presence of one or two minor alleles of the cytochrome P450, subfamily 2C polypeptide 8 gene (CYP2C8) polymorphism rs1934951 was an independent prognostic marker associated with development of osteonecrosis of the jaw in multiple myeloma patients treated with bisphosphonates. The aim of this study was to validate the frequency of SNP rs193451 in 79 patients with multiple myeloma. In 9 (22%) patients developing osteonecrosis of the jaw, a heterozygous genotype was found, in contrast with those who did not develop osteonecrosis of the jaw (n=4, 11%) or healthy individuals (n=6, 13%). We found no differences in the cumulative risk of developing osteonecrosis of the jaw between patients homozygous and heterozygous for the major allele. We were unable to confirm a significant association between this polymorphism and the risk of developing osteonecrosis of the jaw.