Substantia nigra hyperechogenicity and brain ventricular size as biomarkers of early dementia with Lewy bodies

• Published in: Alzheimer's research & therapy 2024-10, Vol.16 (1), p.227-11, Article 227
• Main Authors: Planas-Ballvé, Anna, Rios, Jose, Gea, Mireia, Rabaneda-Lombarte, Neus, Ispierto, Lourdes, Grau, Laia, Jiménez, Marta, Cáceres, Cynthia, Martínez, Sílvia, Beyer, Katrin, Álvarez, Ramiro, Pastor, Pau, Vilas, Dolores
• Format: Article
• Language: English
• Subjects: Advertising executives; Aged; Alzheimer Disease - diagnostic imaging; Alzheimer's disease; Biological markers; Biomarkers; Brain; Brain stem; Cerebral Ventricles - diagnostic imaging; Cerebral Ventricles - pathology; Cross-Sectional Studies; Dementia with Lewy bodies; Diagnosis; Diagnosis, Ultrasonic; Female; Frontal horns of lateral ventricles; Humans; Lewy body disease; Lewy Body Disease - diagnostic imaging; Male; Medical examination; Medical imaging equipment; Nervous system diseases; Neurological research; Parkinson Disease - diagnostic imaging; Prospective Studies; Size; Substantia nigra; Substantia Nigra - diagnostic imaging; Substantia Nigra - pathology; Third ventricle width; Transcranial sonography; Ultrasonography, Doppler, Transcranial - methods; Ultrasound imaging; Ventricles
• ISSN: 1758-9193; 1758-9193
• DOI: 10.1186/s13195-024-01590-w

Diagnosis of dementia with Lewy bodies (DLB) is challenging, especially in the earlier stages of the disease, owing to the clinical overlap with other neurodegenerative diseases such as Alzheimer's (AD) and Parkinson's disease (PD). We aimed to identify the transcranial sonography (TCS) parameters that can help us to detect early DLB patients. In this cross-sectional study, we prospectively recruited newly diagnosed DLB patients with less than 3 years from the onset of cognitive symptoms. For comparison purposes, we also included AD and PD patients, with a disease duration of less than 3 years, and a control group. TCS was performed to assess the substantia nigra (SN) echogenicity, the width of the third ventricle, and the frontal horns of the lateral ventricles. Subsequently, TCS images were analyzed with the medical image viewer Horos in order to quantify the intensity of the echogenicity of the SN. Univariate analysis and a logistic regression model were used to identify which variables can predict the diagnosis of DLB. One hundred and seven participants were included (23 DLB, 26 AD, 27 PD and 31 controls). The median age of DLB patients was 75(72-77) years, with a disease duration of 2 years. DLB and PD patients showed higher SN hyperechogenicity rates (72.73% and 81.82%, respectively) and a greater area of the SN compared to AD patients and controls (p