Iminosugar Amino Acid idoBR1 Reduces Inflammatory Responses in Microglia

(1) Background. Inflammation is reported to be a key factor in neurodegeneration. The microglia are immune cells present in the central nervous system; their activation results in the release of inflammatory cytokines and is thought to be related to aging and neurodegenerative disorders, such as Alz...

Full description

Saved in:
Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2022-05, Vol.27 (10), p.3342
Main Authors: Olajide, Olumayokun A, Iwuanyanwu, Victoria U, Banjo, Owolabi W, Kato, Atsushi, Penkova, Yana B, Fleet, George W J, Nash, Robert J
Format: Article
Language:English
Subjects:
(2R,3R,4R,5S)-3,4,5-trihydroxypiperidine-2-carboxylic acid
Aging
Alzheimer's disease
Amino acids
Amino Acids - metabolism
Animals
Anti-Inflammatory Agents - metabolism
Anti-Inflammatory Agents - pharmacology
Brain
Carboxylic acids
Central nervous system
Cucumbers
Cucumis sativus
Cytokines
Dengue fever
Dexamethasone
Diabetic retinopathy
Experiments
iminosugar amino acid-idoBR1
Immune system
Inflammation
Interleukin 6
lipopolysaccharide
Lipopolysaccharides
Mice
Microglia
microglia cell line
Neurotoxicity
NF-κB protein
Nitric oxide
Nitric Oxide Synthase Type II - metabolism
Nonsteroidal anti-inflammatory drugs
Parkinson's disease
pro-inflammatory factors
Proteins
Tumor necrosis factor-α
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:(1) Background. Inflammation is reported to be a key factor in neurodegeneration. The microglia are immune cells present in the central nervous system; their activation results in the release of inflammatory cytokines and is thought to be related to aging and neurodegenerative disorders, such as Alzheimer's disease. (2) Methods. A mouse BV-2 microglia cell line was activated using LPS and the anti-inflammatory cucumber-derived iminosugar amino acid idoBR1, (2 ,3 ,4 ,5 )-3,4,5-trihydroxypiperidine-2-carboxylic acid, was used alongside dexamethasone as the control to determine whether it could reduce the inflammatory responses. (3) Results. A dose-dependent reduction in the LPS-induced production of the proinflammatory factors TNFα, IL-6, and nitric oxide and the transcription factor NF- B was found. (4) Conclusions. Further investigations of the anti-inflammatory effects of idoBR1 in other models of neurodegenerative diseases are warranted.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27103342