Stimuli Responsive, Programmable DNA Nanodevices for Biomedical Applications

Of the multiple areas of applications of DNA nanotechnology, stimuli-responsive nanodevices have emerged as an elite branch of research owing to the advantages of molecular programmability of DNA structures and stimuli-responsiveness of motifs and DNA itself. These classes of devices present multipl...

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Bibliographic Details
Published in:Frontiers in chemistry 2021-06, Vol.9, p.704234-704234
Main Authors: Singh, Udisha, Morya, Vinod, Datta, Bhaskar, Ghoroi, Chinmay, Bhatia, Dhiraj
Format: Article
Language:English
Subjects:
biomedical applications
biosensing
Chemistry
DNA nanotechnology
stimulus responsive devices
therapeutics
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Summary:Of the multiple areas of applications of DNA nanotechnology, stimuli-responsive nanodevices have emerged as an elite branch of research owing to the advantages of molecular programmability of DNA structures and stimuli-responsiveness of motifs and DNA itself. These classes of devices present multiples areas to explore for basic and applied science using dynamic DNA nanotechnology. Herein, we take the stake in the recent progress of this fast-growing sub-area of DNA nanotechnology. We discuss different stimuli, motifs, scaffolds, and mechanisms of stimuli-responsive behaviours of DNA nanodevices with appropriate examples. Similarly, we present a multitude of biological applications that have been explored using DNA nanodevices, such as biosensing, in vivo pH-mapping, drug delivery, and therapy. We conclude by discussing the challenges and opportunities as well as future prospects of this emerging research area within DNA nanotechnology.
ISSN:2296-2646
2296-2646
DOI:10.3389/fchem.2021.704234