Anti-Alzheimer's Natural Products Derived from Plant Endophytic Fungi

Alzheimer's is the most common cause of dementia worldwide and seriously affects patients' daily tasks. Plant endophytic fungi are known for providing novel and unique secondary metabolites with diverse activities. This review focuses primarily on the published research regarding anti-Alzh...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2023-02, Vol.28 (5), p.2259
Main Authors: Zhu, Juntai, Wang, Zimo, Song, Lixia, Fu, Wanxin, Liu, Li
Format: Article
Language:English
Subjects:
Alkaloids - metabolism
Alzheimer's disease
Alzheimer’s
Antioxidants
Apoptosis
bioactivities
Biological products
Biological Products - chemistry
Chemical research
Composition
Dementia
Dementia disorders
Drug therapy
Endophytes
Endophytes - chemistry
endophytic fungi
Fermentation
Free radicals
Fungi
Fungi - chemistry
Health aspects
Humans
Literature reviews
Metabolites
Natural products
Peptides
Pharmaceutical research
Polyketides
Polyketides - chemistry
Review
Secondary metabolites
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Summary:Alzheimer's is the most common cause of dementia worldwide and seriously affects patients' daily tasks. Plant endophytic fungi are known for providing novel and unique secondary metabolites with diverse activities. This review focuses primarily on the published research regarding anti-Alzheimer's natural products derived from endophytic fungi between 2002 and 2022. Following a thorough review of the literature, 468 compounds with anti-Alzheimer's-related activities are reviewed and classified based on their structural skeletons, primarily including alkaloids, peptides, polyketides, terpenoids, and sterides. The classification, occurrences, and bioactivities of these natural products from endophytic fungi are summarized in detail. Our results provide a reference on endophytic fungi natural products that may assist in the development of new anti-Alzheimer's compounds.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28052259